The 49ers are all set to face off against the New York Giants on Thursday, Sept. 21. This week 3 game is slated to kick off at 8:15 ET and will be shown on Amazon Prime Video. San Francisco enters this contest as a 10-point favorite, and the over/under total stands at 44.5. Can the Giants come out on top as the favorite? Our 49ers vs. Giants predictions can be found below.
49ers vs. Giants Odds
- Spread: 49ers -10
- Total 44.5
Game Info
- Date: Thursday, Sept. 21
- Time: 8:15 ET
- Location: Levi’s Stadium, Santa Clara CA
- TV: Amazon Prime Video
Giants Betting Trends
- Over their last five games, the Giants have an over/under record of 2-3 and are 2-3 vs. the spread.
- New York has a 2-3 record in their last five road games. In this stretch, they averaged 21 points per game while allowing 27. The team also performed well vs the spread at 3-2.
- Looking back on the team’s last five games as the underdog, the Giants have a straight up record of 1-4. Their record vs the spread in these games was 3-2.
49ers Betting Trends
- In their last five games, the 49ers have an over/under record of 4-1 and are 5-0 vs. the spread.
- When looking at their past five home matchups, San Francisco has an ATS record of 2-2-1 while averaging 25 per game. The team went 4-1 overall in these games.
- As the betting favorite, the 49ers have an ATS record of 4-0-1 in their last five games. In these matchups, their straight-up record was 5-0.
Do the Giants Have a Shot at a Road Win?
Going into week 3, New York is 4th in the NFC East with an overall record of 1-1. Within the NFC, they find themselves in 11th place. When it comes to the spread, the Giants have a 0-2 record. Heading into week 3, their scoring margin is at -18.5 (per game).
In their previous game, the Giants defeated the Cardinals with a final score of 31-28. The Giants secured the win, but they didn’t cover the spread against the Cardinals while being favored by 4.5. The over/under line for the game was 39.5 points, and the combined total points scored went over, reaching 59 points.
Looking at their performance on offense, Daniel Jones threw for 321 yards while completing 70% of his passes. On the ground, the Giants rushed the ball 27 times for 127 yards. The team’s third-down performance stood at 7/12.
When it came to defense, the Giants yielded 379 yards of total offense to Arizona. Among these yards, 151 were attributed to the rushing game, while 228 yards were given up through 31 attempts by the Cardinals’ offense.
Can the 49ers Please the Home Santa Clara Crowd?
Over the course of two games, the 49ers have put together a record of 2-0. This positions them 1st in the NFC-West and 2nd in the NFC. Currently, the 49ers hold a 1-0-1 record against the spread. In every game played so far, they have been the favored team.
In their most recent game, the 49ers beat the Rams by a score of 30-23. Favored by 7, the 49ers finished with a push vs. the spread. The over/under line for their game was set at 45 points, and the teams exceeded it with a combined total of 53 points.
In their matchup against the Rams, the 49ers ran the ball 28 times, with Christian McCaffrey emerging as the top rusher with 116 yards. In the passing game, Brock Purdy finished with 25 passes, resulting in 206 yards and a passer rating of 93.
Defensively, the 49ers allowed 386 total yards of offense against Los Angeles. Of these yards, 89 were surrendered on the ground, while the team’s secondary conceded 297 yards on 55 pass attempts.
49ers vs. Giants Player Prop
Christian McCaffrey has been a force to be reckoned with this year. In 2023, he currently leads the NFL with 42 rush attempts and an average of 134.0 rushing yards per game. He started the season strong, rushing for 152 yards in Week 1 and 116 yards in Week 2.
Since joining the 49ers, McCaffrey has consistently performed well. After a gradual introduction in his debut week, he exceeded 79.5 rushing yards in eight of the subsequent 15 games. Over that 15-game span, he averaged 80.9 yards per game, with a median of 84 yards.
Looking ahead to the short-week matchup against the Giants, the 49ers may opt to lighten McCaffrey’s workload, especially if they secure a comfortable lead. However, even with fewer carries, he has a favorable chance of surpassing 79.5 rushing yards. The Giants have already allowed a whopping 212 rushing yards to running backs this season.
The Prop: Christian McCaffrey Over 80.5 Rushing Yards (-103)
49ers vs. Giants Predictions
San Francisco started as 9.5-point favorites at home, and the lines have since moved in their favor to -10.
According to the betting splits, 75% of the tickets are on the 49ers against the spread, but only 61% of the handle is in that direction.
Yes, Saquon Barkley is not playing for the Giants, but New York isn’t as bad as they have played in the first two weeks of the season. I believe they will keep this one relatively close and cover the spread.
The Pick: Giants +10 | -110 at Fanduel Sportsbook