Purdue vs. Wisconsin Predictions, Odds & Picks (Friday, Sept. 22)

Purdue Boilermakers quarterback Hudson Card (1) hands the ball off to Purdue Boilermakers running back Devin Mockobee (45) during the NCAA football game against the Syracuse Orange, Wednesday, July 12, 2023, at Ross-Ade Stadium in West Lafayette, Ind.
Image Credit: Alex Martin/Journal and Courier / USA TODAY NETWORK

The Purdue Boilermakers are set to face the Wisconsin Badgers in a weekday Big Ten matchup on Friday, Sept. 22. Kickoff is scheduled for 7 p.m. ET while airing on FS1. Wisconsin enters this game as 5.5-point favorites with the total set at 53.5. How will this one play out? Let’s dive into the Purdue vs. Wisconsin predictions, odds, and picks below.

Purdue vs. Wisconsin Odds

  • Spread: Wisconsin -5.5
  • Total: 53.5

Game Info

  • Date: Friday, Sept. 22
  • Time: 7 pm ET
  • Location: Ross-Ade Stadium — West Lafayette, IN
  • TV: FS1

Purdue Betting Trends

  • Purdue are 1-4 ATS in their last 5 games.
  • Purdue are 1-4 SU in their last 5 games.

Wisconsin Betting Trends

  • Wisconsin are 2-5 ATS in their last 7 games.
  • The total has gone UNDER in 6 of Wisconsin’s last 8 games.

Purdue vs. Wisconsin Predictions

It appears that the sharp bettors could be taking Purdue against the spread here.

Looking at the betting splits, 64% of the betting tickets are on Wisconsin -6, but 58% of the money is backing Purdue +6. This implies that there are larger bets (aka “sharp money”) being placed on Purdue against the spread.

Wisconsin beat Buffalo and Georgia Southern but stumbled in its only road matchup at Washington State by a score of 31-22.

Purdue lost 39-35 against Fresno State, bounced back to beat Virginia Tech 24-17 on the road, then dropped another home contest 35-20 against Syracuse last week. The problem last week was due to the rushing ability of Syracuse QB Garrett Shrader, who put up 195 yards on the ground. Even though Wisconsin QB Tanner Mordecai sometimes uses his legs, he’s nowhere near that level.

I’m looking for the Boilermakers to keep this one close at home. Wisconsin is 2-5 against the spread in its last seven games, and the Badgers went 1-4 ATS last season in road conference games.

The Pick: Purdue +6 | -110 at FanDuel Sportsbook