USC vs. Notre Dame Predictions, Odds & Picks – Saturday, Nov. 26

Nov 19, 2022; Pasadena, California, USA; Southern California Trojans running back Darwin Barlow (22) celebrates his touchdown scored against the UCLA Bruins during the second half at the Rose Bowl.
Image Credit: Gary A. Vasquez-USA TODAY Sports

It’s a rivalry week feast in the college football world! Continuing that trend, USC is set to face Notre Dame on Saturday, Nov. 26. The game is scheduled for 7:30 pm ET while airing on ABC. USC enters this game as 5.5-point favorites with the total set at 64.5. How will this one play out? Let’s dive into the USC vs. Notre Dame predictions below.

USC vs. Notre Dame Odds

  • Spread: USC -5.5
  • Total: 64.5

Odds via FanDuel Sportsbook. New to FanDuel? Check out our FanDuel Sportsbook Review to find out how to redeem a $1,000 risk-free bet!

Game Info

  • Date: Saturday, Nov. 26
  • Time: 7:30 pm ET
  • Location: Los Angeles Memorial Coliseum — Los Angeles, CA
  • TV: ABC

USC Betting Trends

  • USC is 7-4 ATS this season
  • The Over is 8-3 in USC games this season
  • USC is 6-4 ATS as favorites this season
  • The Over is 5-0 in USC games in their last 5 games
  • USC is 11-0 as favorites in their last 11 games
  • USC is 5-2 ATS at home in their last 7 games

Notre Dame Betting Trends

  • Notre Dame is 6-5 ATS this season
  • The Over is 6-4-1 in Notre Dame games this season
  • Notre Dame is 3-0 ATS as underdogs this season
  • Notre Dame is 13-5 ATS in their last 18 games
  • The Over is 5-0 in Notre Dame games in their last 5 games
  • Notre Dame is 5-1 ATS as underdogs in their last 6 games

USC vs. Notre Dame Predictions

In order to make accurate USC vs. Notre Dame predictions, our sports betting model has sorted through thousands of historical college football games to find similar matchups. We can then draw comparisons and find value based on this analysis. 

The model found that the total is higher than 100% of the 12 most historically similar matchups. That warrants a play on Under 64.5 total points.

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The Pick: Under 64.5 | -110 at FanDuel Sportsbook