Rams vs. 49ers Player Props, Predictions & Odds – Week 2

Christian McCaffrey #23 of the San Francisco 49ers warms up prior to the game against the Kansas City Chiefs at Levi's Stadium on October 23, 2022 in Santa Clara, California.
Image Credit: Ezra Shaw/Getty Images

The Rams are set to face the San Francisco 49ers on Sunday, Sep 17. The game is scheduled for 4:05 ET while airing on FOX. San Francisco enters this game as 8-point favorites with the total set at 45. How will this one play out? Let’s dive into the Rams vs 49ers predictions below.

Rams vs. 49ers Odds

  • Spread: 49ers -8
  • Total 45

Game Info

  • Date: Sunday, Sep 17
  • Time: 4:05 ET
  • Location: SoFi Stadium — Inglewood CA
  • TV: FOX

49ers Betting Trends

  • Over their last five games, the 49ers have an over/under record of 2-3 and are 4-1 vs. the spread.
  • Across their last five road contests, San Francisco has been good against the spread posting a mark of 3-2. Their overall mark in these games was 4-1, while averaging 26 points per game.
  • In their last five games as the betting favorite, the 49ers have a strong straight up record of 5-0. In addition, their ATS record was 4-1 in these scenarios.

Rams Betting Trends

  • In their last five games, the Rams have an over/under record of 4-1 and are 3-2 vs. the spread.
  • In their last ten games home from home, the Rams have a straight up record of 3-7 while going 4-5-1 vs. the spread. The team averaged 16 points per game in this stretch.
  • Spanning across their last five games as the betting underdog, the Rams have gone 3-2 vs the spread. Their overall record in these games was 2-3.

Are the 49ers Ready for a Road Win?

The 49ers opened their season by traveling to face the Steelers, and they managed to come away with a 30-7 victory. Heading into the game, the 49ers were favored by 1. Their 23-point win was enough to cover the spread.

Offensively, Brock Purdy finished with 220 passing yards while completing 65% of his passes. On the ground, the 49ers rushed the ball 34 times for 188 yards. The team converted 6 of 13 third-down opportunites.

Defensively, the 49ers intercepted the Steelers two times while allowing 198 passing yards. The team’s rush defense gave up 41 yards on 10 attempts.

Do the Rams Have What it Takes at Home?

In their opening game of the season, the Rams hit the road to take on the Seahawks and secured a 30-13 win. Going into the game, the Rams were actually 4.5-point underdogs. This resulted in an ATS win for the Rams.

On offense, the Seahawks finished with 40 rushing attempts, and Kyren Williams was the leading rusher with 52 yards. In the passing game, Matthew Stafford threw the ball 38 times, accumulating 334 yards and a passer rating of 91.

When it came to defense, the Rams yielded 180 yards of total offense to Seattle. Among these yards, 85 were attributed to the rushing game, while 95 yards were given up through 26 attempts by the Seahawks’ offense.

Rams vs. 49ers Player Prop

Christian McCaffrey comes in with a rushing yards prop of 65.5 for this week’s game. Betting the over offers a payout of -118, which translates to implied odds of 54%, while the under pays out at -114 (53%).

In one game, Christian McCaffrey has rushed the ball 22 times for 152 yards against the Pittsburgh Steelers. Currently, he ranks 1st among running backs in rushing yards gained. McCaffrey comes in with a good matchup against a Rams defense which is allowing 4.7 per carry. I’ll be going with the over, which comes with a payout of -118.

The Prop: Christian McCaffrey Over 65.5 Rushing Yards (-118)

Rams vs. 49ers Predictions

Pay attention to the betting splits at DraftKings, 68% of the betting tickets are on the 49ers against the spread. However, only 52% of the betting handle is backing San Francisco -8. That signifies larger bets and potential sharp action on the Rams +8. 

Los Angeles’ pass defense did a good job slowing down Seattle in their most recent game. Even though they are 8-point underdogs at home, I like them to cover vs. San Francisco and keep the game closer than what most people expect.

The Pick: Rams +8 | -113 at Fanduel Sportsbook

More NFL Props & Predictions 

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