Brewers Vs Padres Odds: Streaking San Diego A Slim Favorite

San Diego Padres third baseman Manny Machado swings his bat and is about to connect with a baseball that ends up as a double during a game against the San Francisco Giants
Image Credit: Darren Yamashita-USA TODAY Sports

Before breaking down Brewers vs Padres odds for Monday’s opener of a three-game series at Petco Park, here’s a quick reminder of these franchises’ shared history: Both entered MLB together in 1969, with the Brewers spending their first year as the Seattle Pilots. And in 54 seasons since, neither has won a World Series — in fact, the franchises have combined for just three World Series appearances.

The good news for Brewers and Padres fans? Through the first quarter of the 2022 campaign, both squads look like legit threats to end their respective title droughts. Entering Monday, San Diego and Milwaukee sport MLB’s third- and fifth-best records, respectively. And both are in a groove right now, with the Brewers having won five of their last seven and the Padres returning home after capping a 7-2 road trip with four straight wins.

Which team has the edge in Monday night’s matchup? dives into Brewers vs Padres odds for what bookmakers have pegged as a near pick ’em contest.

Odds via DraftKings and updated as of 11:20 a.m. ET on May 23.

Milwaukee Brewers (26-15) vs San Diego Padres (27-14)

Milwaukee Brewers first baseman Rowdy Tellez flips his bat and trots to first base after hitting a two-run home against the Cincinnati Reds
Image Credit: Mark Hoffman-Milwaukee Journal-Sentinel/USA TODAY Network

First Pitch/TV: 9:40 p.m. ET/MLB.TV
Moneyline: Padres -120/Brewers +100
Brewers (-1.5) +170/Padres (+1.5) -200
Total: 7.5
(Over -115/Under -105)

Pitching matchup: RHP Adrian Houser (3-4, 3.22 ERA, 1.35 WHIP) vs RHP Nick Martinez (2-2, 3.89 ERA, 1.33 WHIP) 

Season series: First meeting. Milwaukee took last year’s season series 5-2, winning all three games at Petco Park in San Diego.

Did you know: Following their three-game weekend sweep of the Giants in San Francisco, the Padres overtaken the New York Mets and New York Yankees as baseball’s most profitable team. San Diego is at +9.61 units (meaning if you wagered $100 on every Padres game this season, you’d be up $961).

About the Brewers

Hits & Misses: Milwaukee’s three-game winning streak was halted in Sunday’s 8-2 home loss to the Nationals. Still, the Brewers arrive in San Diego on a 6-2 roll. They’ve posted two shutouts during this run and scored five-plus runs four times. Milwaukee went 8-1 on the road from April 12-May 6 but is just 3-5 in its last eight as a visitor. The Brewers are 5th in MLB in OPS (.729) and 6th in runs (4.78 per game). 1B Rowdy Tellez is tied for 4th in MLB with 32 RBI, and he’s for the team lead in homers with nine. On the mound, Milwaukee ninth in both team ERA (3.46) and WHIP (1.18), and fourth in opponents’ batting average (.219). The Brewers lead the NL Central by three games over the Cardinals.

Houser vs San Diego: Houser is coming off a gem against Atlanta, allowing just one unearned run on four hits with two walks and six strikeouts in six innings. However, he didn’t get any run support in a 3-0 loss. That strong showing followed two dreadful outings — both against the Reds — in which Houser surrendered a combined 12 runs (seven earned) in nine innings. The 29-year-old from Oklahoma has surrendered just one home run in 36.1 innings. Houser faced the Padres twice last year and gave up a combined two runs on six hits and three walks with six strikeouts in 9.2 innings. Milwaukee won both games (4-2 on the road, 6-5 at home).

Key injuries: SS Willy Adames (left ankle sprain) is on the 10-day injured list and is not expected to return until at least early June. Also, Milwaukee SP Freddy Peralta (shoulder) landed on the IL after being forced to leave Sunday’s start against Washington. 

About the Padres 

Hits & Misses: After a pair of one-run victories on Friday (8-7) and Saturday (2-1), San Diego thrashed the Giants 10-1 in Sunday’s series finale. 3B Manny Machado went 3-for-4 with three doubles and a triple, three runs and two RBI. Machado now leads MLB with a .374 batting average, and his 1.065 OPS is tied for second with Aaron Judge. Both trail only Mike Trout (1.133 OPS). Machado is a huge reason why the Padres have baseball’s third-best record, behind only the Yankees and Dodgers. San Diego, which hasn’t had SS Fernando Tatis (broken wrist) all season, trails L.A. by just a half-game in the NL West. The Friars own baseball’s best road record (16-7) but are a modest 10-7 at Petco Park. 

Martinez vs Milwaukee: After six straight starts to being his career with San Diego, Martinez pitched out of the bullpen for the first time Wednesday in Philadelphia and yielded just two hits while striking out six in four innings. The right-hander’s most recent start was on May 11 at home against the Cubs, and he gave up five runs on four hits in four innings. He didn’t factor in the decision, as San Diego lost 7-5 at home. In his three starts prior to facing Chicago, Martinez was sharp, allowing a combined five runs in 16.2 innings (2.70 ERA). Martinez, who pitched four seasons for Texas (2014-17) before spending the next four campaigns in Japan, has never faced the Brewers.

Key injuries: In addition to Tatis, San Diego has five RPs on the 60-day IL. OF Matt Beaty (shoulder) hit the 10-day IL last week and is out indefinitely. 

Notable Trends

San Diego Padres catcher Austin Nola raises his right arm to high-five an unseen teammate after hitting a home run against the San Francisco Giants
Image Credit: Kelley L Cox-USA TODAY Sports
  • MIL is mired in slumps of 3-8 as an underdog (all on the road) and 0-5 vs. the NL West
  • SD is on positive runs of 5-1 overall, 13-5 as a favorite and 9-3 vs the NL Central
  • Both teams are 7-1 in their last eight series openers
  • Under is 4-1 in MIL’s last five overall
  • Over is 5-1-1 in MIL’s last seven on the road
  • Under for SD is on runs of 4-1 overall and 11-5 at home
  • MIL is 6-2 in its last eight vs SD overall and 9-3 in its last 12 games at Petco Park
  • Under is 8-3 in the last 11 series meetings overall
  • Under is 5-1 in the last six Brewers-Padres clashes in SD

Brewers vs Padres Odds and Action

UPDATE 6:15 P.M. ET: About 3.5 hours prior to first pitch, San Diego is a modest -120 favorite in DraftKings’ Brewers vs Padres odds market. This matchup opened at Padres -115, dipped to a -110 pick ’em early this morning, then rose to -120 by midmorning. Ticket count is practically dead even, while money is just shy of 2/1 on the short underdog Brewers.

The total opened at 7.5, made multiple trips to 8 (Under -115), and has been stable since midmorning at 7.5 (Over -115). That said, tickets and money are running 7/1 on the Over.

UPDATE 11:30 A.M. ET: BetMGM installed San Diego as a slight -115 home favorite in the wee hours this morning, and the moneyline hasn’t changed, with Milwaukee at -105. The total hit the board at 7.5/Over -120 but has nudged up to 8/Under -115.

Check back prior to first pitch for additional Brewers vs Padres odds and action updates.