The No. 18 Louisville Cardinals (6-1) are set to host the No. 20 Duke Blue Devils (5-2) in a crucial ACC showdown this Saturday. Both teams are looking to bounce back from recent losses and keep their ACC title hopes alive. The Cardinals are coming off their first loss of the season, while the Blue Devils have dropped two of their last three games.
Below, we have your Duke vs. Louisville predictions, odds, and picks.
Duke vs. Louisville Odds
Moneyline: Duke Blue Devils +160 (DraftKings) / Louisville Cardinals -192 (DraftKings)
Spread: -4.5 – Duke Blue Devils -110 (DraftKings) / Louisville Cardinals -110 (Bet365)
Total: 46.0 – -110 (BetMGM) / -110 (BetMGM)
Game Info
Date: Saturday, Oct. 28
Time: 03:30 PM
Location: L&N Federal Credit Union Stadium – Louisville, KY
TV: ESPN
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Duke Blue Devils Betting Trends
- On the road, Duke Blue Devils are 1 and 1 this season.
- Against the spread this season, Duke Blue Devils are 4 and 3.
- Against the spread on the road, Duke Blue Devils are 1 and 1.
Louisville Cardinals Betting Trends
- At home, Louisville Cardinals are 3 and 0 this season.
- Against the spread this season, Louisville Cardinals are 3 and 1.
- Against the spread at home, Louisville Cardinals are 3 and 0.
Duke vs. Louisville Game Preview
The Cardinals are coming off a bye week following their first loss of the season to Pittsburgh. Despite the setback, they have shown resilience this season, winning all three of their home games by double digits. They will be looking to leverage their home-field advantage and strong defense, which has helped them cover the spread in eight straight home games. However, they will be without offensive lineman Renato Brown due to a knee injury, which could impact their offensive line performance.
On the other side, Duke’s offense has been struggling, particularly in the passing game. Starting quarterback Riley Leonard has been dealing with an injury and is questionable for this game. If Leonard is unable to play, the Blue Devils will likely rely heavily on their strong rushing attack, led by veteran running backs Jordan Waters and Jaquez Moore. Despite their recent losses, Duke has covered the spread in eight of its last 11 games, including five of its last six against ACC teams.
This game could come down to the wire, with both teams eager to avoid a second ACC loss. The key matchup to watch will be Duke’s rushing attack against Louisville’s defense. If the Cardinals can contain the Blue Devils’ ground game, they could secure a crucial home victory. However, if Duke’s running backs can break through, the Blue Devils might just pull off an upset.
Duke vs. Louisville Predictions
The Duke Blue Devils have shown resilience this season, covering the spread in eight of their last 11 games. This trend, combined with their strong rushing attack, makes them a solid pick against the spread. Even if starting quarterback Riley Leonard is unable to play, the Blue Devils have proven they can rely on their ground game to keep them competitive. Veteran running backs Jordan Waters and Jaquez Moore have combined for more than 800 rushing yards this season, providing a consistent offensive threat.
On the other hand, the Louisville Cardinals will be without key offensive lineman Renato Brown, which could impact their offensive performance. Despite their strong home record, the loss of Brown could create vulnerabilities in their offensive line that Duke could exploit. Furthermore, while Louisville’s defense has been strong, they will be tested by Duke’s potent rushing attack. Given these factors, Duke is a strong pick against the spread for this matchup.
The Pick: Duke Blue Devils +4.5 | -110 at DraftKings