College Hoops: Duke vs. Louisville Predictions, Odds & Picks (Monday, Feb. 20)

Nov 30, 2022; Durham, North Carolina, USA; Duke Blue Devils guard Jeremy Roach (3) encourages the fans during the second half against the Ohio State Buckeyes at Cameron Indoor Stadium. The Blue Devils won 81-72.
Image Credit: Rob Kinnan-USA TODAY Sports

If the season ended today, Duke would very likely make the NCAA Tournament. However, the Blue Devils can’t afford too many blemishes on their resume. Losing to the 4-23 Louisville Cardinals would definitely stand out as a bad loss. So will Duke pull it out on their home floor, and can the Blue Devils cover the mammoth 19-point spread? Let’s dive into the Duke vs. Louisville predictions below.

Duke vs. Louisville Odds

  • Spread: Duke -19
  • Total: 137.5

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Game Info

  • Date: Monday, Feb. 20
  • Time: 7 pm ET ET
  • Location: Cameron Indoor Stadium, Durham, NC
  • TV: ESPN

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Duke vs. Louisville Predictions

Let’s cut to the chase here. Duke is going to win this game. However, the best bet doesn’t lie with the moneyline or spread. The Blue Devils have been a defense-first squad this season, ranking 30th in adjusted defensive efficiency (per KenPom.com) and 266th in tempo. On top of that, Duke has gone under the total in four of its last five games. Looking closer, the Blue Devils have gone under the total in seven straight games with the over/under listed at 137.5 or greater.

This one could be a blowout, which could help the final score fall under the total. Duke will come out with plenty of energy and stifling defense. There’s a chance the Blue Devils will take their foot off the gas pedal if they build a big enough lead in the second half. The starters could get pulled, which definitely helps the under.

The Pick: Under 137.5 | -110 at BetFred Sportsbook