Bills vs. Titans Predictions: Monday Night Football Picks (Week 2)

Derrick Henry #22 of the Tennessee Titans carries the ball during the game against the New York Giants at Nissan Stadium on September 11, 2022 in Nashville, Tennessee.
Image Credit: Justin Ford/Getty Images

The Bills will attempt to avenge losses in back-to-back seasons to the Titans. Last year, they lost a shootout, going for it on fourth and goal instead kicking a game-tying field goal. Josh Allen slipped when attempting a sneak and came up short. 

Things have changed for both teams. So, sports bettors shouldn’t pencil in another shootout for this matchup. What should they expect, and where should bettors wager their money? We’ll look at both teams and provide you with the necessary information to wisely wager your money.

Bills vs. Titans Predictions

For my Bills vs. Titans predictions, I’ll place these wagers at DraftKings Sportsbook.

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Bills vs. Titans Odds

TeamSpreadMoneylineTotal
Titans+10+360O 47.5 (-110)
@ Bills-10-480U 47.5 (-110)

Odds via DraftKings Sportsbook as of 10 pm ET on Sept. 17.

Game Info

  • Date: Monday, Sept. 19
  • Time: 7:15 p.m. ET
  • Location: Highmark Stadium – Orchard Park, NY
  • TV: ESPN

Bills vs. Titans Trends

  • The total opened at 52 points at DraftKings and has steadily dropped through the week to its present total of 47.5 points.
  • The under is 5-2 in the last seven games that the Bills have been favorites.
  • The under is 9-4 in Buffalo’s last 13 games in September.
  • The under is 4-1 in the last five games following a Titans loss against the spread.
  • The under is 4-1 in Tennessee’s last five games against an AFC opponent.
  • The under is 7-3 in Tennessee’s last 10 games in September.

Buffalo Offense: Still in Good Hands

The Bills hung 31 points on the defending Super Bowl champions in Week 1. So, Ken Dorsey’s first game as an offensive coordinator and play-caller couldn’t have gone better. And, of course, Josh Allen was lights out.

Still, there were some interesting nuggets from Buffalo’s opener. According to Sharp Football Stats, the Bills had a 57% rush rate when leading by at least seven points in the second half in 2021. In Week 1, they rushed at a 60% clip in the second half when leading by at least seven points. 

In addition, Buffalo is 24th in plays (58). And, according to Football Outsiders, they’re 23rd in situation-neutral pace this year. 

Can The Titans Avoid A Beatdown?

Tennessee’s offense is built around Derek Henry. Full stop. The Titans even doubled-down on Henry being the offense’s focal point, trading superstar wideout A.J. Brown to the Eagles for a first-round pick they used on raw wideout Treylon Burks. 

Last season, the Titans were tied for the fifth-highest rush rate (51%) in neutral game scripts. Yet, their run-heavy tendencies didn’t end there. They had the highest rush rate (41%) when trailing by at least four points and ran at a 59% clip when leading by at least four points.

Tennessee also plays at a methodical pace. They’re 22nd in plays (60) this year and 16th in situation-neutral pace. Last season, they were 21st in situation-neutral pace.

Bills vs. Titans Predictions

Bettors should erase the 34-31 Monday Night Football game from last year from their memories. Derrick Henry has since suffered a foot injury that required surgery and hasn’t run like a monster since early last year. The Titans also no longer have Brown or Julio Jones in their receiver room. Obviously, Jones’s stint with the Titans was forgettable. Nevertheless, he was effective early in the year and hauled in three receptions for 59 yards against the Bills. Now, Tennessee’s receiving room is an unimposing group headlined by Robert Woods, who is less than 12 months removed from tearing his ACL.

Therefore, the Bills are rightfully commanding favorites. However, their No. 2 receiver, Gabriel Davis, popped up on the injury report on Saturday with an ankle injury. He was limited in practice, leaving his status for the game in doubt. 

The Bills can handle their business without the field-stretching Davis. Still, it might prompt them to play slightly differently, possibly leaning on the running game more often. Additionally, as I noted above, they ran a bit more to salt away the lead in Week 1 than they did under similar conditions in 2021. 

Finally, if the Titans flip this game on its head and lead, their bread is buttered on the ground with King Henry. As a result, my favorite bet is the game’s under for 47.5 points at DraftKings Sportsbook. 

Pick: Under 47.5 Points | -110 at DraftKings Sportsbook