Fantasy Football News: Week 16 NFL Injury Report (Sunday, 12/21)

Welcome back to the most stressful Sunday of the fantasy football season. We’re in the semifinals now, which means every decision matters, every snap counts, and one bad injury designation can absolutely torpedo your week. We’ve got you covered with today’s Week 16 NFL injury report, featuring the offensive skill players that matter for fantasy football purposes.

Let me be straight with you: Week 16 is a bloodbath from an injury standpoint. This is the point in the season where bodies are breaking down, guys are playing through pain, and the waiver wire is more important than your draft picks from September.

Let’s take a look at some of the biggest fantasy football injuries and situations to monitor.

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Fantasy Football News Today: Week 16 NFL Injury Report

Here’s our NFL Injury Report update as of 1 p.m. EST Sunday morning. There are plenty of household names already ruled out for Sunday’s games.

NFL Players Out Today (12/21)

• UPDATED: 1 p.m. EST

Keon Coleman (BUF, WR) – OUT (Scratch) – Coleman won’t play for Buffalo today as a healthy inactive.

Woody Marks (HOU, RB) – EXPECTED to be OUT. Could be a lot of Nick Chubb and Mr. Jordan.

Patrick Mahomes (QB, KC) – OUT (ACL): Unless you’ve been living under a rock, you know the reigning MVP is sidelined with a season-ending injury. The entire Chiefs offense becomes a guessing game. That being said, Gardner Minshew is very capable, and the Tians are soft tanking, with absolutely nobody on the defensive side of the ball that matters other than Jeff Simmons.

Rashee Rice (WR, KC) – OUT (Concussion): The receiving corps just lost one of its best route-runners. Xavier Worthy and Kelce will have to shoulder the load, and it might finally be time for a Worthy explosion game.

Alvin Kamara (RB, NO) – OUT (Knee): A nightmare scenario for Saints fantasy managers. But here’s where it gets interesting: Devin Neal is ALSO OUT (Hamstring). The entire Saints backfield just got gutted. That means rookie Audric Estime is about to get volume against the Jets. Is he startable? Absolutely. Is he a lottery ticket at best? Also absolutely. But in a semifinal, sometimes you take what the injury gods give you.

David Njoku (TE, CLE) – OUT (Knee): The Browns’ starting tight end is sidelined. Harold Fannin has seen insane volume with Shedeur Sander at the helm, but the Bills have been extremely good against the position.

Ricky Pearsall (WR, SF) – OUT (Knee/Ankle): Jauan Jennings and the run game become even more important for San Francisco.

Zonovan Knight (RB, ARI) – OUT (Ankle): It’s the Michael Carter show today. Expect AZ to keep airing it out, as they own the highest neutral pass rate in the NFL.

Additional OUT Designations: Devaughn Vele (NO), Bhayshul Tuten (JAX), Dylan Sampson (CLE), Mason Taylor (NYJ), Andre Baccellia (ARI).

Questionable NFL Players Today (12/21)

These guys might go, might not. Check the inactive lists 90 minutes before kickoff.

• UPDATED: 11:55 a.m. EST

Tee Higgins (WR, CIN) – ACTIVE.

Woody Marks (RB, HOU) – Q (Ankle): Here’s the situation: Nick Chubb is expected to return from his rib injury. If both are active, Marks becomes a complementary back in a committee.

Christian Kirk (WR, HOU) – Q (Illness): Late-week illnesses are usually “game-time decisions,” but nine times out of ten, guys with minor illnesses suit up by Sunday. Kirk is likely to play, but verify before kickoff.

Quentin Johnston (WR, LAC) – Q (Groin): UPDATE: Johnston WILL play today. Groins are unpredictable. If Johnston plays, he’s potentially limited. If he sits, Keenan Allen is a bigger part of the offense.

Mason Tipton (WR, NO) – Q (Illness): Like Kirk, illnesses at this point in the week are usually precautionary. Expect him to play, but confirm.

Gunnar Helm (TE, TEN) – Q (Toe): A toe injury on a tight end is less of a concern than a hamstring, but verify his status before committing. Helm is starting to turn it on this season, a promising rookie on a bad team.

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Baker Mayfield TB QB TB @ CAR Live	o229.5 -113 u229.5 -111	o228.5 -137 u228.5 -137	o231.5 -112 u231.5 -112	o228.5 -144 u228.5 -113	o236.5 +110 u236.5 -145	o231.5 -121 u231.5 -112	o230.5 -115 u230.5 -115	o230.5 -137 u230.5 -137	-	-
Brady Cook NYJ QB NYJ @ NO Live	o167.5 -111 u167.5 -113	o167.5 -137 u167.5 -137	o169.5 -112 u169.5 -112	o166.5 -133 u166.5 -123	o164.5 -140 u164.5 +105	o168.5 -114 u168.5 -117	o165.5 -115 u165.5 -115	o170.5 -137 u170.5 -137	-	-
Bryce Young CAR QB TB @ CAR Live	o206.5 -112 u206.5 -112	o207.5 -137 u207.5 -137	o207.5 -112 u207.5 -112	o206.5 -126 u206.5 -129	o207.5 -115 u207.5 -115	o208.5 -120 u208.5 -112	o205.5 -120 u205.5 -110	o207.5 -137 u207.5 -137	-	-
Cameron Ward TEN QB KC @ TEN Live	o175.5 -113 u175.5 -111	o180.5 -137 u180.5 -137	o180.5 -112 u180.5 -112	o181.5 -128 u181.5 -128	o180.5 -115 u180.5 -115	o179.5 -118 u179.5 -113	o175.5 -115 u175.5 -115	o181.5 -137 u181.5 -137	-	-
Dak Prescott DAL QB LAC @ DAL Live	o253.5 -112 u253.5 -112	o250.5 -137 u250.5 -137	o249.5 -112 u249.5 -112	o252.5 -136 u252.5 -119	o256.5 -115 u256.5 -115	o253.5 -114 u253.5 -115	o250.5 -120 u250.5 -110	o254.5 -137 u254.5 -137	-	-
Gardner Minshew KC QB KC @ TEN Live	o214.5 -113 u214.5 -111	o212.5 -137 u212.5 -137	o212.5 -112 u212.5 -112	o213.5 -125 u213.5 -131	o221.5 -115 u221.5 -115	o215.5 -120 u215.5 -112	o210.5 -115 u210.5 -115	o212.5 -137 u212.5 -137	-	-
Jaxson Dart NYG QB MIN @ NYG Live	o189.5 -112 u189.5 -112	o191.5 -137 u191.5 -137	o191.5 -112 u191.5 -112	o195.5 -120 u195.5 -135	o193.5 -118 u193.5 -110	o190.5 -114 u190.5 -117	o190.5 -110 u190.5 -120	o197.5 -137 u197.5 -137	-	-
J.J. McCarthy MIN QB MIN @ NYG Live	o185.5 -111 u185.5 -113	o189.5 -137 u189.5 -137	o187.5 -112 u187.5 -112	o188.5 -135 u188.5 -121	o192.5 -115 u192.5 -115	o189.5 -114 u189.5 -115	o195.5 -110 u195.5 -120	o188.5 -137 u188.5 -137	-	-
Joe Burrow CIN QB CIN @ MIA Live	o260.5 -113 u260.5 -111	o260.5 -137 u260.5 -137	o259.5 -112 u259.5 -112	o259.5 -128 u259.5 -128	o263.5 -115 u263.5 -115	o261.5 -115 u261.5 -114	o255.5 -120 u255.5 -110	o258.5 -137 u258.5 -137	-	-
Josh Allen BUF QB BUF @ CLE Live	o210.5 -111 u210.5 -113	o208.5 -137 u208.5 -137	o207.5 -112 u207.5 -112	o216.5 -114 u216.5 -142	o211.5 -115 u211.5 -115	o208.5 -105 u208.5 -128	o200.5 -115 u200.5 -115	o211.5 -137 u211.5 -137	-	-
Justin Herbert LAC QB LAC @ DAL Live	o236.5 -112 u236.5 -112	o237.5 -137 u237.5 -137	o237.5 -112 u237.5 -112	o233.5 -133 u233.5 -123	o231.5 -115 u231.5 -115	o235.5 +100 u235.5 -135	o235.5 -110 u235.5 -120	o242.5 -137 u242.5 -137	-	-
Quinn Ewers MIA QB CIN @ MIA Live	o181.5 -112 u181.5 -112	o185.5 -137 u185.5 -137	o179.5 -112 u179.5 -112	o185.5 -125 u185.5 -131	o187.5 -115 u187.5 -115	o181.5 -121 u181.5 -111	o175.5 -120 u175.5 -110	o185.5 -137 u185.5 -137	-	-
Shedeur Sanders CLE QB BUF @ CLE Live	o178.5 -112 u178.5 -112	o180.5 -137 u180.5 -137	o177.5 -112 u177.5 -112	o179.5 -121 u179.5 -135	o180.5 -115 u180.5 -115	o178.5 -113 u178.5 -120	o175.5 -110 u175.5 -120	o180.5 -137 u180.5 -137	-	-
Tua Tagovailoa MIA QB CIN @ MIA Today 1:00 PM ET	o218.5 -112 u218.5 -112	o219.5 -137 u219.5 -137	o218.5 -114 u218.5 -114	o218.5 -125 u218.5 -131	o188.5 -115 u188.5 -115	o218.5 -115 u218.5 -115	o220.5 -110 u220.5 -120	o219.5 -137 u219.5 -137	-	-
Tyler Shough NO QB NYJ @ NO Live	o214.5 -113 u214.5 -111	o217.5 -137 u217.5 -137	o213.5 -112 u213.5 -112	o218.5 -126 u218.5 -129	o214.5 -115 u214.5 -115	o215.5 -125 u215.5 -110	o215.5 -110 u215.5 -120	o216.5 -137 u216.5 -137	-	-
Bo Nix DEN QB JAX @ DEN Today 4:05 PM ET	o242.5 -111 u242.5 -113	o243.5 -137 u243.5 -137	o240.5 -112 u240.5 -112	o236.5 -149 u236.5 -109	o243.5 -115 u243.5 -115	o241.5 -115 u241.5 -115	o240.5 -115 u240.5 -115	o241.5 -137 u241.5 -137	-	-
Jacoby Brissett ARI QB ATL @ ARI Today 4:05 PM ET	o256.5 -112 u256.5 -112	o254.5 -137 u254.5 -137	o258.5 -112 u258.5 -112	o258.5 -131 u258.5 -125	o254.5 -115 u254.5 -115	o257.5 -125 u257.5 -108	o250.5 -120 u250.5 -110	o1.5 -137 u1.5 -137	-	-
Kirk Cousins ATL QB ATL @ ARI Today 4:05 PM ET	o229.5 -111 u229.5 -113	o231.5 -137 u231.5 -137	o231.5 -112 u231.5 -112	o225.5 -147 u225.5 -111	o228.5 -110 u228.5 -118	o230.5 -114 u230.5 -115	o225.5 -115 u225.5 -115	o229.5 -137 u229.5 -137	-	-
Trevor Lawrence JAX QB JAX @ DEN Today 4:05 PM ET	o225.5 -111 u225.5 -113	o225.5 -137 u225.5 -137	o225.5 -112 u225.5 -112	o226.5 -117 u226.5 -138	o225.5 -115 u225.5 -115	o225.5 -114 u225.5 -115	o220.5 -120 u220.5 -110	o222.5 -137 u222.5 -137	-	-
Aaron Rodgers PIT QB PIT @ DET Today 4:25 PM ET	o231.5 -111 u231.5 -113	o228.5 -137 u228.5 -137	o234.5 -112 u234.5 -112	o225.5 -151 u225.5 -108	o234.5 -115 u234.5 -115	o233.5 -115 u233.5 -114	o230.5 -115 u230.5 -115	o228.5 -137 u228.5 -137	-	-
C.J. Stroud HOU QB LV @ HOU Today 4:25 PM ET	o225.5 -111 u225.5 -113	o227.5 -137 u227.5 -137	o224.5 -112 u224.5 -112	o231.5 -120 u231.5 -136	o219.5 -115 u219.5 -115	o224.5 -111 u224.5 -121	o225.5 -110 u225.5 -120	o227.5 -137 u227.5 -137	-	-
Geno Smith LV QB LV @ HOU Today 4:25 PM ET	o185.5 -112 u185.5 -112	o179.5 -137 u179.5 -137	o179.5 -112 u179.5 -112	o179.5 -128 u179.5 -128	o188.5 -115 u188.5 -115	o181.5 -108 u181.5 -125	o175.5 -115 u175.5 -115	o182.5 -137 u182.5 -137	-	-
Jared Goff DET QB PIT @ DET Today 4:25 PM ET	o268.5 -111 u268.5 -113	o265.5 -137 u265.5 -137	o267.5 -112 u267.5 -112	o261.5 -147 u261.5 -111	o270.5 -115 u270.5 -115	o269.5 -114 u269.5 -115	o265.5 -120 u265.5 -110	o1.5 -137 u1.5 -137	-	-
Drake Maye NE QB NE @ BAL Today 8:20 PM ET	o243.5 -112 u243.5 -112	o242.5 -137 u242.5 -137	o242.5 -112 u242.5 -112	o240.5 -153 u240.5 -107	o238.5 -130 u238.5 +100	o242.5 -125 u242.5 -108	o240.5 -120 u240.5 -110	o242.5 -137 u242.5 -137	-	-
Lamar Jackson BAL QB NE @ BAL Today 8:20 PM ET	o215.5 -112 u215.5 -112	o212.5 -137 u212.5 -137	o212.5 -112 u212.5 -112	o212.5 -120 u212.5 -135	o209.5 -115 u209.5 -115	o212.5 -114 u212.5 -115	o210.5 -120 u210.5 -110	o209.5 -137 u209.5 -137	-	-
Brock Purdy SF QB SF @ IND Tomorrow 8:15 PM ET	o246.5 -113 u246.5 -111	o248.5 -137 u248.5 -137	o243.5 -114 u243.5 -114	o242.5 -144 u242.5 -112	o245.5 -115 u245.5 -115	o243.5 -115 u243.5 -115	o240.5 -115 u240.5 -115	o243.5 -137 u243.5 -137	-	-
Philip Rivers IND QB SF @ IND Tomorrow 8:15 PM ET	o158.5 -112 u158.5 -112	o159.5 -137 u159.5 -137	o157.5 -114 u157.5 -114	o154.5 -149 u154.5 -111	o159.5 -115 u159.5 -115	o159.5 -120 u159.5 -112	o160.5 -105 u160.5 -125	o157.5 -137 u157.5 -137	-	-

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Last updated: Dec 21, 2025 1:37 PM | Showing 10 of 27 props

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