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NFL Bets Today: Steelers vs Lions Predictions, Odds & Props (12/21)

Justin Carlucci

Justin Carlucci

Last updated: December 21, 2025

Amon Ra St. Brown – Steelers vs Lions Predictions, Odds, Props & Picks – Dec. 21, 2025

We’ve got you covered for the best Steelers vs Lions predictions and player props for today! This is an unbelievably critical game for both teams, and we should see some fireworks in this one. This game has “season on the line” energy for both sides, and the market’s giving us plenty to work with on the spread, total, and player props.

Our NFL betting expert Justin Carlucci dives into the numbers. Let’s go.

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Steelers-Lions Preview and Predictions (12/21)

This Steelers vs Lions matchup checks every box for a high-variance, high-ceiling offensive game-script. There are plenty of mouthwatering spots to try and attack.

  • Books have Detroit laying around a touchdown at home with a total in the low 50s, signaling real respect for this Lions offense.
  • Detroit is hanging top-tier scoring numbers (over 30 points per game) and ranks near the top of the league in red-zone TD rate, while the Steelers’ defense could yield much more time in the pocket without T.J. Watt​

Detroit’s defense is the wild card. The front has had strong stretches this season and can be disruptive, but the back end has been vulnerable, especially against elite receivers and accurate quarterbacks.

Losing safety Kerby Joseph to injured reserve coming into this week only magnifies those issues. Joseph had been a ball-hawking presence in the middle of the field, and his absence opens up windows for Rodgers to attack intermediate and deep between the numbers.

When all is said and done, the most likely story looks like Detroit’s offense sustaining drives and cashing in red-zone trips, while Pittsburgh answers in spurts behind Aaron Rodgers and DK Metcalf—but not often enough.

Steelers vs Lions Odds

  • Spread: Lions -7.5 (-105)
  • Moneyline: Steelers +315
  • Game Total (O/U): 57.5

How to Watch Steelers vs. Lions

  • Date: Sunday, December 21, 2025.
  • Kickoff: 4:25 p.m. ET.
  • Stadium: Ford Field, Detroit (indoor dome)
  • ​​TV: NFL Sunday Ticket; Regional CBS Coverage

NFL LIVE PLAYER PROP ODDS

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NFL Expert Picks: Steelers vs Lions Best Player Prop Bets

This could be the most exciting game of Week 16 from a points-scoring perspective. Check out some Steelers vs Lions props on Underdog:

Steelers vs Lions props - dec 21, 2025

PICK: Amon-Ra St. Brown> 85.5 Receiving Yards

The Steelers are giving up the 7th-highest catchable target rate and 10th-highest catch rate in the NFL, according to Fantasy Points. When the going gets tough in Detroit, Jared Goff always turns to ARSB. He should do it again in a great matchup and massive game total.

PICK: Jameson Williams > 69.5 Receiving Yards

Yes, I think you can play both of these guys. Williams has been incredible since Dan Campbell has taken over play-calling duties. His target rate rivals St. Brown’s (especially with Sam LaPorta out), and there’s a world where both of these guys go over these lines– and I think it’s reasonable.

Love running a pick’em slip back with Metcalf on it too, with the Steelers in catch-up mode.

Good luck!

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