Ohio State vs. Michigan Predictions, Odds & Picks – Saturday, Nov. 26

Dec 31, 2021; Miami Gardens, FL, USA; Michigan Wolverines quarterback J.J. McCarthy (9) throws against the Georgia Bulldogs during the fourth quarter in the Orange Bowl college football CFP national semifinal game at Hard Rock Stadium.
Image Credit: Jasen Vinlove-USA TODAY Sports

It’s the big one: Ohio State is set to face Michigan on Saturday, Nov. 26. The game is scheduled for 12 pm ET while airing on FOX. Ohio State enters this game as 7.5-point favorites with the total set at 56. How will this one play out? Let’s dive into the Ohio State vs. Michigan predictions below.

Ohio State vs. Michigan Odds

  • Spread: Ohio State -7.5
  • Total: 56

Odds via FanDuel Sportsbook. New to FanDuel? Check out our FanDuel Sportsbook Review to find out how to bet $5 to get $125.

Game Info

  • Date: Saturday, Nov. 26
  • Time: 12 pm ET
  • Location: Ohio Stadium, Columbus, OH
  • TV: FOX

Ohio State Betting Trends

  • Ohio State is 5-5-1 ATS this season
  • The Over is 8-3 in Ohio State games this season
  • Ohio State is 5-5-1 ATS as favorites this season
  • The Over is 8-1 in Ohio State games in their last 9 games
  • Ohio State is 10-0 as favorites in their last 10 games
  • Ohio State is 4-0-1 ATS at home in their last 5 games

Michigan Betting Trends

  • Michigan is 5-4 ATS this season
  • The Over is 2-7 in Michigan games this season
  • Michigan is 2-1 ATS on the road this season
  • Michigan is 16-6 ATS in their last 22 games
  • The Over is 2-7 in Michigan games in their last 9 games
  • Michigan is 2-16 as underdogs in their last 18 games

Ohio State vs. Michigan Predictions

This is a classic clash of offense vs. defense. The Buckeyes will try to outscore the Wolverines with their high-flying offense, but the Wolverines boast one of the best defenses in the nation, ranking second in points allowed, rushing defense, and fifth in passing defense.

Both teams have run through their schedule with relative ease (other than a couple of interesting games — especially on Michigan’s side), and this will be the toughest matchup each will face.

Ultimately, Ohio State comes away with a big win at home while getting their revenge. However, this spread is too high, and the Wolverines should be able to keep it within a touchdown.

Revenge is on the mind of Ohio State, and losing to Michigan in The Horseshoe while missing the Big Ten championship again would be soul-crushing. I’m taking Ohio State to win, but Michigan to cover.

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The Pick: Michigan +7.5 | -110 at FanDuel Sportsbook