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Whether you’re a seasoned bettor or just getting started, our experts break down every angle of the weekly NFL action – from traditional spreads and totals to the most profitable player props and same-game parlays.
Jeff Edelstein, Keith Eyster, and Justin Bales will be coming back on Friday at 4 ET to break down all of the Week 4 action. View the show below!
Here’s the Week 4 schedule:
Thursday, September 25, 2025
- Seattle @ Arizona – 8:15 PM (Prime Video) – State Farm Stadium, Glendale, AZ – SEA -1.5, O/U: 43.5
Sunday, September 28, 2025
Early Games (1:00 PM ET)
- Washington @ Atlanta – CBS – Mercedes-Benz Stadium, Atlanta, GA – WSH -1.5, O/U: 44.5
- New Orleans @ Buffalo – CBS – Highmark Stadium, Orchard Park, NY – BUF -15.5, O/U: 47.5
- Cleveland @ Detroit – FOX – Ford Field, Detroit, MI – DET -9.5, O/U: 44.5
- Carolina @ New England – FOX – Gillette Stadium, Foxborough, MA – NE -5.5, O/U: 42.5
- Los Angeles Chargers @ New York Jets – CBS – MetLife Stadium, East Rutherford, NJ – LAC -6.5, O/U: 44.5
- Philadelphia @ Tampa Bay – FOX – Raymond James Stadium, Tampa, FL – PHI -3.5, O/U: 43.5
- Tennessee @ Houston – CBS – NRG Stadium, Houston, TX – HOU -7.5, O/U: 38.5
Late Afternoon Games
- Indianapolis @ Los Angeles Rams – 4:05 PM FOX – SoFi Stadium, Inglewood, CA – LAR -3.5, O/U: 50.5
- Jacksonville @ San Francisco – 4:05 PM FOX – Levi’s Stadium, Santa Clara, CA – SF -3.5, O/U: 47.5
- Baltimore @ Kansas City – 4:25 PM CBS – GEHA Field at Arrowhead Stadium, Kansas City, MO – BAL -2.5, O/U: 48.5
- Chicago @ Las Vegas – 4:25 PM CBS – Allegiant Stadium, Las Vegas, NV – CHI -1.5, O/U: 47.5
International Game
- Minnesota @ Pittsburgh – 9:30 AM (NFL Network/NFL+) – Croke Park, Dublin, Ireland – MIN -2.5, O/U: 40.5
Sunday Night Football
- Green Bay @ Dallas – 8:20 PM NBC – AT&T Stadium, Arlington, TX – GB -6.5, O/U: 47.5
Monday, September 29, 2025
- New York Giants @ Miami – 7:15 PM – Hard Rock Stadium, Miami Gardens, FL – MIA -2.5, O/U: 45.5
- Cincinnati @ Denver – 8:15 PM – Empower Field at Mile High, Denver, CO – DEN -7.5, O/U: 44.5
