The 2025 NFL Week 13 Injury Report contains several key players who could significantly impact each team and the betting market.
Our analyst Juan Carlos Blanco analyzes the biggest names dealing with NFL Week 13 injuries.
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NFL Week 13 Injury Report: Key Players
Even with big names such as C.J. Stroud and Jaxson Dart returning to action on Sunday, we continue to have some noteworthy players on the injury report in Week 13 at all four skill positions.
In this article each week, we’ll highlight some noteworthy players who have opened the practice week with an injury designation of some sort and offer some quick hits on the expected impact of their absences, if those come to fruition.
NOTE: This article is posted on Saturday. Make sure to check on the updated injury statuses before locking in your NFL Week 13 plays. Good luck!
Quarterbacks
Baker Mayfield, Buccaneers, QUESTIONABLE (shoulder)
The good news regarding Mayfield is that the veteran signal-caller appears to be on track to play Sunday against the Cardinals, after going from a missed Wednesday practice to a limited showing Thursday and full participation Friday. Mayfield suffered his injury in the first half of an ugly Week 12 loss to the Rams and gave way to Teddy Bridgewater for the final two quarters as a result.
Head coach Todd Bowles spoke highly of Mayfield’s condition after Friday’s practice, saying his quarterback looked good all the way around and was in line to play versus Arizona.
Assuming that holds true, Mayfield will also have the benefit of Chris Godwin filling a more robust role than in the wideout’s Week 12 return while also getting the versatile Bucky Irving back from an extended absence, albeit while likely playing abbreviated snaps.
J.J. McCarthy, Vikings, OUT (concussion)
It’s arguable whether McCarthy’s absence is a net positive for the struggling Vikings, considering the young quarterback’s body of work over the previous three games (51.6% completion rate, 2:6 TD:INT). A reset may be just what the second-year signal-caller needs, especially with a daunting road matchup against the Seahawks on Sunday.
McCarthy will be replaced by rookie Max Brosmer, whose outlook is naturally pretty bleak in its own right. Brosmer handled first-team reps throughout the week and won’t be going into Sunday completely cold in terms of regular-season action at the NFL level, as he’s attempted eight passes thus far. The only safety net behind Brosmer is Desmond Ridder, who’s expected to be promoted from the practice squad Saturday.
With Brosmer at the controls and the Seahawks defense opposing him, the outlook for Justin Jefferson and Jordan Addison, not to mention the running back duo of Aaron Jones and Jordan Mason, is extremely muted.
Jayden Daniels, Commanders, OUT (elbow)
Daniels couldn’t recover sufficiently during the Commanders’ Week 12 bye to suit up for Sunday night’s matchup against the Broncos, although the second-year quarterback did put in a pair of limited showings in practice and was said to be making significant progress in his recovery according to head coach Dan Quinn.
Daniels’ ongoing absence means Marcus Mariota will make another start for Washington in an exceedingly difficult matchup against a Broncos defense that’s also getting Patrick Surtain back from a pectoral injury. Mariota has curiously thrown for exactly 213 yards in three straight starts while posting a 4:3 TD:INT and adding 99 rushing yards, but his matchup is far from ideal despite being at home.
Running Backs
Bucky Irving, Buccaneers, QUESTIONABLE (foot/shoulder)
Irving is set to make his return after a seven-game absence due to his pair of injuries, and the versatle back was able to practice in full all week during Week 13 prep.
However, the second-year pro is due to fill a limited role in his first game back, meaning Rachaad White and Sean Tucker should still see their fair share of opportunities against a Cardinals defense surrendering 130.2 rushing yards per road game, and 142.3 over the last three contests overall.
Alvin Kamara, Saints, OUT (knee)
Kamara will sit out his first game of the season against the Dolphins on Sunday after missing practice all week due to his MCL injury.
The veteran’s absence will afford rookie sixth-round pick Devin Neal, who has 17 carries for 61 yards and a 12-64 receiving line over his first seven NFL games. Neal, who finished out his college career with consecutive 1,200-yard seasons at Kansas, could handle a heavy workload considering his only serious competition for carries against a Dolphins defense allowing 142.6 rushing yards per game figures to be Audric Estime.
Other notable short-term RB injuries to monitor: Emari Demercado, Cardinals, OUT (ankle); Bam Knight, Cardinals, QUESTIONABLE (knee); Jerome Ford, Browns, QUESTIONABLE (hamstring)
Wide Receivers
Chris Olave, Saints, QUESTIONABLE (back)
Olave suffered a back injury in practice on Wednesday and then sat out Thursday’s session before returning in limited fashion Friday.
The star wideout reportedly performed well within the context of his limitations during that final session of the week, but head coach Kellen Moore suggested Olave’s status is likely to come down to pregame warmups.
Olave is averaging a robust 9.7 targets per game, so any absence on his part will create plenty of opportunity for the likes of Devaughn Vele, Mason Tipton, and Kevin Austin, who would serve as Tyler Shough’s top three targets at the position. Additionally, all of Taysom Hill, Juwan Johnson, and Foster Moreau would likely be in for much more work collectively, especially with Alvin Kamara also sidelined.
Marvin Harrison, Jr., Cardinals, QUESTIONABLE (appendix)
Harrison managed to practice in limited fashion all week, giving him an opportunity to return from a two-game absence Sunday against the Buccaneers.
If Harrison is held out for at least one more game, it sets up Michael Wilson, Greg Dortch, and Trey McBride for another very busy afternoon. Wilson has been Jacoby Brissett’s favorite target over the two games Harrison has missed with a total of 33 passes being directed his way, a massive level of opportunity Wilson has parlayed into a 25-303-0 line. However, Dortch has remained very relevant with a 12-119-2 tally on 15 targets, while McBride has gone for 19-194-1 on 21 targets in the same span.
If Baker Mayfield suits up for Tampa Bay as expected, Brissett could be in for a similarly high-volume day as in his last two games as Arizona looks to keep pace.
Drake London, Falcons, OUT (knee)
London will sit out a second straight game Sunday against the Jets after once again missing practice all week. The talented wideout’s absence in Week 12 against the Saints led to Darnell Mooney serving as the No. 1 receiver for new starter Kirk Cousins and posting a 3-74-1 line on three targets.
Current No. 2 receiver David Sills also caught his first NFL TD on three targets as well, while tight end Kyle Pitts drew five looks. Cousins attempted just 23 passes in the easy win and may not have to do much more than that versus New York, although when he does drop back, he’ll face a secondary that lost its most talented piece by far in Sauce Gardner at the trade deadline.
Other notable short-term WR injuries to monitor: Elic Ayomanor, Titans, QUESTIONABLE (hamstring); Joshua Palmer, Bills, QUESTIONABLE (back); Wan’Dale Robinson, Giants, QUESTIONABLE (ankle); Darius Slayton, Giants, QUESTIONABLE (hamstring)
Tight Ends
Dalton Kincaid, Bills, QUESTIONABLE (hamstring)
Kincaid was able to finish off the week with two limited practices, putting him in play to possibly return from a two-game absence against the Steelers on Sunday.
The talented tight end’s time on the sideline hasn’t really led to any significant production boost for another Bills pass catcher in an offense that spreads the ball around plenty, and the duo of Dawson Knox and Jackson Hawes would be in line to once again spell Kincaid if he sits out one more contest.
Chig Okonkwo, Titans, QUESTIONABLE (foot)
Okonkwo sandwiched a pair of limited practices around a Thursday absence this week, and his status could come down to how he feels in pregame warmups ahead of Sunday’s game against the Jaguars.
If Okonkwo, who’s averaging 4.2 targets per game, sits out, promising rookie Gunnar Helm, who boasts a 10-80-0 line on 12 targets in the last two contests, would have an even bigger role than usual.
Darren Waller, Dolphins, QUESTIONABLE (IR, pectoral)
Waller managed to practice in limited fashion all week, and although he remains on injured reserve, he put himself in position to potentially be activated Saturday afternoon and return from a four-game absence Sunday against New Orleans.
If Waller is active, he’ll cut into the snap count of Greg Dulcich, who’s shown some signs of life in Mike McDaniel’s offense the last three games with eight catches for 89 yards on 13 targets.
Other notable short-term TE injuries to monitor: Michael Mayer, Raiders, OUT (ankle)
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