NFL Week 12 Key Injuries & Top Value Targets

Oct 27, 2024; Santa Clara, California, USA; San Francisco 49ers wide receiver Deebo Samuel Sr (1) carries the ball against the Dallas Cowboys during the third quarter at Levi's Stadium.
Image Credit: Kelley L Cox-Imagn Images

Understanding how injuries reshape NFL matchups is essential for uncovering hidden value in player props. Week 12 features two key games with substantial injury implications: the 49ers vs. Packers and Buccaneers vs. Giants.

Let’s dive into how injuries will influence these contests and which props offer the most value for Sunday’s slate. 

NFL Week 12 Injury Report: Top Value Player Prop Targets

Sam Pasco analyzes three key matchups in Week 12 and breaks down his best bets.

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Game 1: San Francisco 49ers @ Green Bay Packers 

Overview: 

The 49ers, battling injury woes, face a surging Packers squad at Lambeau Field. San Francisco will start backup QB Brandon Allen in place of Brock Purdy (shoulder), while other key players, including George Kittle (hamstring) and Nick Bosa (oblique), are either out or hobbled. The Packers, relatively healthy aside from CB Jaire Alexander, are 7-3 and poised to exploit San Francisco’s vulnerabilities. 

Injury Impact and Prop Betting Opportunities: 

With Brandon Allen starting, expect the 49ers to lean heavily on Christian McCaffrey and Deebo Samuel. Kyle Shanahan is likely to employ a run-heavy scheme to limit Allen’s exposure and focus on safe, high-percentage plays. 

Top Props to Target: 

  • Deebo Samuel Over 59.5 Rush + Rec Yards (-114): Samuel has exceeded this mark in three consecutive road games. The Packers’ defense struggles against versatile playmakers, setting up a strong game for Samuel. 
  • George Kittle Anytime TD (+320): Despite his hamstring issues, Kittle has delivered in big moments, scoring in his last three road games. In the red zone, Allen may rely on Kittle’s reliability. 
  • Brandon Allen Under 29.5 Pass Attempts (-122): The 49ers’ likely game plan revolves around minimizing Allen’s dropbacks, especially against a competent Packers pass rush. 

Game 2: Tampa Bay Buccaneers @ New York Giants 

Overview: 

The Giants enter Week 12 in disarray, releasing Daniel Jones and starting Tommy DeVito. The Bucs, meanwhile, welcome back WR Mike Evans from a hamstring injury. Tampa Bay aims to snap a four-game skid against a 2-8 Giants team that’s struggled mightily on both sides of the ball.

Injury Impact and Prop Betting Opportunities: 

Mike Evans’ return transforms the Bucs’ passing attack. With his presence demanding defensive attention, Baker Mayfield’s efficiency should improve, and Cade Otton will likely continue to capitalize in the short-to-intermediate range. 

Top Props to Target: 

  • Mike Evans Anytime TD (+120): Evans is rested and ready, returning as the Bucs’ top red-zone threat. Against a Giants defense that ranks near the bottom in coverage metrics, Evans is a strong bet to score. 
  • Baker Mayfield Over 22.5 Completions (+100): Mayfield has surpassed this total in 70% of his games this season. With Evans back, expect a high-volume passing game, especially if the Giants stack the box. 
  • Cade Otton Anytime TD (+200): Otton has become a red-zone favorite during Evans’ absence, and his role should remain significant even with Evans back in the lineup. 

For the Giants, DeVito faces a tall task against a Tampa Bay defense looking to rebound. Target Tommy DeVito Under 203.5 Pass + Rush Yards (-114), as the Bucs’ defensive line will likely dominate the trenches. 

Conclusion 

Top Picks Recap: 

  • Deebo Samuel Over 59.5 Rush + Rec Yards (-114) 
  • George Kittle Anytime TD (+320) 
  • Mike Evans Anytime TD (+120)
  • Baker Mayfield Over 22.5 Completions (+100)