Here’s our NFL DFS Injury Report Week 12, and it’s loaded with star players like Joe Burrow.
Our analyst Juan Carlos Blanco analyzes the biggest names dealing with NFL Week 12 injuries for November 23, 2025.
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NFL DFS Week 12 Injury Report: Who’s Out Today
In this article each week, we’ll highlight some noteworthy players who have opened the practice week with an injury designation of some sort and offer some quick hits on the expected impact of their absences, if those come to fruition.
NOTE: This article is posted early on Sunday morning. Make sure to check on the updated injury statuses before locking in your NFL Week 12 plays. Good luck!
Quarterbacks
Joe Burrow, Bengals (toe)
Burrow’s availability will naturally be the subject of intense scrutiny leading into Sunday morning, as the star signal-caller appears to have a better than 50% chance of making his return from his toe injury Sunday against the Patriots. Burrow managed to practice in full both Wednesday and Thursday before putting in a limited Friday session.
Head coach Zac Taylor said Friday he’d take as much time as he had available to make a final decision on whether it would be Burrow or Joe Flacco under center against New England, but whoever is at the controls will have to work without Ja’Marr Chase, who’s sidelined due to a one-game suspension. That will leave Cincinnati with one truly consistent target in Tee Higgins, who’s likely to see plenty of Christian Gonzalez’s sticky man coverage without Chase factoring into the equation.
Aaron Rodgers, Steelers (wrist)
Rodgers is another likely game-time decision this week, as the small left wrist fracture he suffered in Week 11 against the Bengals kept him to two limited practices this week. Rodgers previously said the biggest factor in whether he’d play would come down to whether he felt he could protect himself adequately throughout the course of a game.
If the future Hall of Famer is ultimately sidelined against the Bears, Mason Rudolph, who has no shortage of experience filling in as a starter for multi-game stretches, would be at the controls of Pittsburgh’s offense against a very short-handed Bears defense.
Michael Penix, Jr., Falcons (IR, knee)
The knee injury that knocked Penix out of the Week 11 overtime loss to the Panthers turned out to be a partially torn ACL that will sideline the second-year signal-caller the rest of the season. That leaves maligned veteran Kirk Cousins to helm the Falcons’ air attack moving forward, beginning with a road divisional clash against the Saints on Sunday.
Cousins has not looked very competent or comfortable during his three appearances (one start) to date, completing just 61.5% of his passes for 250 yards with no touchdowns or interceptions. To make matters more challenging in Week 12, he’ll be working without top target Drake London (knee) against a Saints defense that tends to play up to the typically raucous environment of its home field.
Running Back
Josh Jacobs, Packers, QUESTIONABLE (knee)
Jacobs missed the second half of the Packers’ Week 11 win over the Giants with what was ultimately deemed to be a knee contusion. He then missed Wednesday’s practice before proceeding to limited participation Thursday and Friday and drawing the questionable tag. Green Bay has both a short turnaround for Week 13 with a Thanksgiving clash against the
Lions on tap and a capable backup in Emanuel Wilson, and both factors could push the coaching staff to play it safe with the star running back as a result. Wilson turned 11 carries into 40 yards and a touchdown and added one reception for nine yards in the second half against New York while working as the lead back.
Kenneth Walker, Seahawks, QUESTIONABLE (lower body)
Walker popped up on the injury report Friday as a limited participant, suddenly casting some doubt on his availability for a favorable Week 12 road matchup against the Titans. The talented back is still expected to play, per head coach Mike Macdonald’s Friday remarks to reporters, noting the limited participation was primarily maintenance-related.
In the case of any setback, backfield mate Zach Charbonnet is well-equipped to take on a larger role, albeit against a Tennessee defense that has played somewhat better of late.
Rhamondre Stevenson, Patriots, QUESTIONABLE (toe)
Stevenson seemingly put himself in position to return from a three-game absence in Sunday’s matchup against the Bengals by putting in a pair of limited practices and a full Friday session this past week. Head coach Mike Vrabel confirmed Stevenson was in line to play barring any setbacks, which sets up an intriguing yet less-than-ideal situation for DFS and betting purposes.
Rookie TreVeyon Henderson has been very productive over the last two contests in particular while posting a 33-209-4 rushing line and a 6-34-1 tally through the air. Henderson’s explosiveness is undoubtedly enticing for the coaching staff, and the matchup against a Bengals defense that’s surrendering an NFL-high 188.2 rushing yards per home game tees up the possibility that both backs are able to put together productive outings.
Other notable short-term RB injuries to monitor: Emari Demercado, Cardinals, OUT (ankle); Isiah Pacheco, Chiefs, OUT (knee); Bucky Irving, Buccaneers, OUT (shoulder/foot); Samaji Perine, Bengals, DOUBTFUL (ankle); Alvin Kamara, Saints, QUESTIONABLE (ankle)
Wide Receivers
Brian Thomas, Jr., Jaguars, OUT (ankle)
Thomas was still listed as questionable at this time last week, but he’s already been ruled out for Sunday’s game against the Cardinals despite being able to practice in limited fashion all three days again this past week.
Thomas’ ongoing absence is expected to continue creating additional opportunities for Jakobi Meyers, who flashed even more rapport with Trevor Lawrence during his second game working with the 2021 first overall pick in Week 11 against the Chargers. Meyers provided a 5-64 line on six targets, and he’ll continue to helm the WR corps Sunday against the Cardinals.
Marvin Harrison, Jr., Cardinals, OUT (appendix)
Arizona will also be missing its No. 1 receiver Sunday, as Harrison once again failed to practice all week following his recent emergency appendectomy. The second-year wideout’s absence in Week 11 against the 49ers led to some interesting developments, as Jacoby Brissett set a new NFL record for completions in a game and Michael Wilson exploded for a 15-185-0 line on 18 targets while operating in Harrison’s usual WR1 spot.
While such a stat line is highly unlikely to come close to being replicated against an aggressive Jaguars defense, Wilson should once again be in for a busy afternoon, and current No. 2 receiver Greg Dortch, who posted six receptions for 66 yards and a touchdown versus San Francisco, should retain a solid role as well. Meanwhile, star tight end Trey McBride will naturally continue to be a key part of the air attack as well and provided a 10-reception, 115-yard, one-touchdown effort in Harrison’s absence.
Drake London, Falcons, OUT (knee)
London was also listed s questionable heading into the Week 11 matchup against the Panthers due to illness, but he ended up playing and turning in another stellar effort prior to getting hurt on the last play of regulation.
The knee injury he suffered went on to keep him out of practice all week, meaning Darnell Mooney, David Sills, KhaDarel Hodge, and Casey Washington will line up as new starter Kirk Cousins’ top WR targets for Sunday’s game against New Orleans.
Mooney has had an especially inefficient season while mustering an unsightly 38.1% catch rate on his 42 targets, but he does have plenty of positive play on tape from his time working with Cousins over the first 15 games of last season (57-873-5 receiving line).
Other notable short-term WR injuries to monitor: Elic Ayomanor, Titans, OUT (hamstring); Calvin Ridley, Titans, QUESTIONABLE (IR, fibula); Tory Horton, Seahawks, OUT (shin); Rashod Bateman, Ravens, OUT (ankle); Matthew Golden, Packers, QUESTIONABLE (shoulder); Chris Godwin, Buccaneers, QUESTIONABLE (lower leg); Dontayvion Wicks, Packers, QUESTIONABLE (calf); Xavier Worthy, QUESTIONABLE (ankle)
Tight End
Sam LaPorta, Lions, OUT (back)
LaPorta went from a Week 11 absence to injured reserve and back surgery within the span of the last week. Head coach Dan Campbell described LaPorta’s chances of returning anytime before the 2026 season as “slim” when asked Friday, and for the foreseeable future, Brock Wright will handle the bulk of Detroit’s tight-end duties.
Wright came into the season with a 56-524-9 line on 71 targets over 58 games across his first four campaigns, so he’s certainly not without experience or ability, especially within a highly functional offense as he steps into.
Other notable short-term TE injuries to monitor: Hunter Long, Jaguars, OUT (hip)
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