Welcome to our College Football Week 9 predictions! We’ll look at the top games of the day, odds on the betting board, and what that means for our favorite CFB picks and player props.
Check our NCAAF News Hub for all things Week 9!
Top Betting Apps in All States
College Football Week 9 Predictions and Picks
It’s Week 9 across college football — and while Friday’s slate isn’t loaded, it sets the table for a monster Saturday featuring ranked battles and playoff hopefuls.
Let’s break down every key matchup and our best CFB picks heading into the weekend.
Boise State at Nevada
Boise State may not be ranked anymore, but the Broncos still hold heavy-favorite status — 21.5-point chalk on the road against Nevada.
Nevada’s offense has struggled to move the ball all year, failing to score more than 20 points in all but one of their games this year. Boise should control this one from start to finish behind a balanced attack behind Maddux Madsen
Pick: Boise State –21.5
North Texas at Charlotte
North Texas has been rolling offensively behind QB Drew Messmaker, who’s thrown a touchdown in every game this season. His lone rough outing came two weeks ago against ranked USF, when he tossed three picks in a 63–36 loss.
Charlotte, meanwhile, has been outmatched in almost every contest, entering at 1–6 with their only win against UAB (who now has a new head coach). Messmaker and company should slice up the 49ers defense with ease.
Pick: North Texas –26.5
Cal at Virginia Tech
This is the most competitive game of the night — and one of the more intriguing Power 4 matchups. Cal comes in as a 4.5-point underdogs fresh off a gritty win over North Carolina.
True freshman QB Jaron-Keawe Sagapolutele impressed in that game with over 200 passing yards, one touchdown, and zero picks. The Bears are 2-1 in ACC play and have scored 20+ in three straight outings. ESPN’s analytics give Tech a 74% win chance, but the Golden Bears’ grit shouldn’t be overlooked.
Pick: Cal +4.5 — Bears keep it close before back-to-back ranked tests next two weeks (Virginia, Louisville).
College Football Week 9 Predictions – Saturday, October 25
Now, moving on to the main slate for Saturday!
UCLA at Indiana
After a rough four-game skid, UCLA has found life again — three straight wins over Penn State, Michigan State, and Maryland. The Bruins’ offense has been humming, though production has dipped slightly each week (42 → 38 → 20 points).
Indiana, though, is one of the most complete teams in the country. QB Fernando Mendoza has been lights-out, nearing 2,000 yards with 21 TDs to just 2 INTs. The Hoosiers have faced a tougher schedule and emerged as legit CFP contender.
Pick: Indiana –25.5 — Mendoza stays efficient as the Hoosiers handle business at home.
No. 8 Ole Miss vs No. 13 Oklahoma
A marquee-ranked clash early in the day. Ole Miss enters 6–1, ranked eighth nationally, coming off a hard-fought loss to Georgia, where they still put up 35 points on the Bulldogs’ defense.
QB John Matier has flashed potential as a dual threat but hasn’t thrown for more than one TD in any game this season, outside the season opener. Oklahoma, meanwhile, has quietly built one of the stingiest defenses in the Big 12 — and they’re playing at home.
Pick: Oklahoma Moneyline
No. 15 Missouri at No. 10 Vanderbilt
Who would’ve guessed a few years ago that Mizzou–Vandy would be a top-15 showdown? Welcome to the NIL era.
Vanderbilt is a 2.5-point favorite after outlasting LSU last week. QB Diego Pavia continues to lead with poise, but Missouri might be the more consistent team. The Tigers’ only loss came by three points to Alabama, and they’ve shown consistent offensive balance.
QB Beau Pribula (the Penn State transfer) must protect the ball — two picks last week nearly cost Mizzou — but his legs give this offense an extra dimension.
Pick: Missouri +2.5 — Tigers bounce back and hand Vandy a rare home loss.
No. 3 Texas A&M at No. 20 LSU
Texas A&M remains one of the few undefeated teams, and the Aggies look every bit the part. QB Marcel Reed has been stellar — 15 TDs, 4 INTs, and a rushing touchdown in three straight games.
The Aggies have scored 31+ points in three straight, though the defense did give up 42 to Arkansas last week (most of it late). LSU, fresh off a deflating loss to Vanderbilt, is trending downward in the AP rankings.
This feels like another statement game for A&M before their stretch run.
Pick: Texas A&M –2.5 — Reed stays hot as the Aggies remain perfect.
CFB Week 9 Predictions Recap
- Boise State rolls Nevada under the lights.
- North Texas covers big behind Drew Messmaker.
- Cal sneaks inside the number vs. Virginia Tech.
- Indiana’s Mendoza continues his breakout.
- Oklahoma edges Ole Miss in a ranked thriller.
- Missouri upsets Vanderbilt on the road.
- Texas A&M keeps its unbeaten run alive in Baton Rouge.
October football keeps heating up — and with playoff races tightening, Week 9 delivers everything from shootouts to statement wins. Buckle up.
