Welcome to our College Football Week 10 predictions! We’ll look at the top games of the day, odds on the betting board, and what that means for our favorite CFB picks and player props.
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College Football Week 10 Predictions and Picks
It’s Week 10 across college football — and while some preseason headliners lost a bit of shine, this weekend still delivers plenty of intrigue.
Ranked clashes in the SEC and Big 12 could shake up playoff hopes, and Friday night kicks things off with a couple of fascinating matchups before a loaded Saturday slate.
Let’s break down every key game and the best bets heading into the weekend. We’ll start with the Friday games.
North Carolina at Syracuse
When: (7:30 p.m. ET, ESPN)
It’s been a rough debut for Bill Belichick’s Tar Heels — just 2–5, losers of four straight, and fresh off an overtime heartbreak against No. 16 Virginia. The offense has been lifeless, failing to crack 20 points in four consecutive games.
Syracuse hasn’t exactly lit it up either. The Orange rank 62nd nationally in total offense but sit 21st in passing at 285.5 yards per game. Their defense, however, struggles across the board (nothing ranked above 97th). Still, UNC’s inefficiency may keep this one ugly.
Pick: Under 45.5 — Neither offense is explosive enough to push this past the mid-40s.
No. 25 Memphis at Rice
When: (7 p.m. ET, ESPN2)
Memphis enters as a 13.5-point favorite and looks poised to roll again after toppling then–No. 18 USF last week. The Tigers have scored 24+ in every game this season and rank top-25 nationally in scoring offense.
Rice, on the other hand, needed double overtime to squeak past UConn and has dropped three of its last four to FAU, Navy, and UTSA.
Pick: Memphis –13.5 — The Tigers rebound in dominant fashion and stay in the AAC race.
CFB Predictions Saturday – Week 10
Let’s dive into the main slate of the weekend.
Penn State at No. 1 Ohio State
When: (Noon, FOX)
This was supposed to be the game of the year in the Big Ten. Instead, a 3–4 Penn State squad walks into Columbus as a 20.5-point underdog.
Matt Patricia’s revamped Ohio State defense has been outstanding, allowing just four touchdowns across seven games with two shutouts. Meanwhile, the Buckeyes’ offense has hit its stride, topping 34 points in three straight. Penn State may scratch a few drives together, but Ohio State’s balance is overwhelming.
Pick: Over 44.5 — The Buckeyes should pour it on, and Penn State scores just enough to push it over.
No. 9 Vanderbilt at No. 20 Texas
When: (Noon, ABC)
It’s a battle of surprise storylines. Vanderbilt, behind steady QB Diego Pavia, has rattled off back-to-back ranked wins (Missouri and LSU). Texas, led by Arch Manning, has shown flashes but remains inconsistent — just 66th nationally in passing (235.9 yards/game).
Pavia hasn’t thrown for 200 yards in three straight, but he’s found ways to win. Manning, meanwhile, comes off a gritty OT win over Mississippi State where he tossed three touchdowns. Texas is a 2.5-point favorite at home, and this feels like a proving-ground game.
Pick: Texas Moneyline — Manning makes just enough plays to hand Vandy its second loss.
No. 15 Virginia at California
When: (3:45 p.m., ESPN2)
Virginia has lived dangerously — three of its last four wins came in overtime, and all by narrow margins. The Cavaliers have flirted with disaster each week, nearly falling to UNC and Louisville before sneaking by Washington State.
Cal, meanwhile, continues to battle. Freshman QB Jaron-Keawe Sagapolutele threw for nearly 300 yards in a double-OT loss to Virginia Tech on the road and has topped 200 yards in every game. The Bears’ resilience at home makes this one intriguing.
Pick: Cal +4.5 — The Golden Bears ride the home crowd to an upset over the worn-down Cavs.
No. 18 Oklahoma at No. 14 Tennessee
When: (7:30 p.m., ABC)
Both teams sit 6–2, making this essentially an elimination game for playoff hopes. Oklahoma’s John Mateer hasn’t looked right since his hand injury — just three TDs over his last three games.
Tennessee QB Joey Aguilar, meanwhile, is heating up with nearly 400 yards last week vs. Kentucky and five TDs in his past three games. The Vols’ offense has momentum.
Pick: Tennessee –3.5 — The Volunteers’ passing attack prevails as Oklahoma’s offense sputters again.
No. 17 Cincinnati at No. 24 Utah
When: (10:15 p.m., ESPN — College GameDay)
A late-night ranked showdown with Big 12 implications. Cincinnati remains tied atop the conference standings after seven straight wins, but this is its first real test.
Utah comes in scorching — fresh off a 53–7 demolition of Colorado — and has scored 42+ in three of the past four. The Utes’ physical run game and rowdy home crowd in Salt Lake City could be too much for the Bearcats.
Pick: Over 54.5 — Expect fireworks as both offenses keep trading blows under the lights.
CFB Week 10 Predictions Recap
October chaos is giving way to November drama — playoff races, coaching pressure, and statement games everywhere you look. From Austin to Salt Lake City, Week 10 promises tension, twists, and one or two seismic upsets. Buckle up.
