Welcome to our College Football Week 13 predictions! We’ll look at the top games of the day, odds on the betting board, and what that means for our favorite CFB picks and player props.
Check our NCAAF News Hub for all things Week 13!
Top Betting Apps in All States
College Football Week 13 Predictions and Picks
Week 13 kicks off without the Friday fireworks we saw last week — no ranked teams in action. A far cry from Oregon’s dismantling of Minnesota or Louisville’s late-game meltdown against Clemson.
Saturday is not loaded. The entire top four is not in serious action, as none of them face ranked opponents:
- No. 1 Ohio State vs. Rutgers: The only curiosity is Rutgers RB Raymond sitting on a perfectly symmetrical statline — 1,000 yards on 200 carries.
- No. 3 Texas A&M hosts Samford: Pure tune-up material.
- No. 4 Georgia hosts 1–9 Charlotte: A Charlotte team that managed… three points against a Bill Belichick–coached UNC earlier this year.
- #2 Indiana is on bye*
No major upsets expected at the top. The real drama sits further down the rankings, beginning with…
No. 22 Missouri at No. 8 Oklahoma Prediction
Line: Oklahoma -6.5
Storyline:
- Oklahoma enters off two gritty outings: edging Tennessee two weeks ago and then surviving Alabama last week with a two-point win.
- The Sooners shut out Alabama in the 4th quarter and held Ty Simpson to just one passing TD.
- QB John Meeteer didn’t do much statistically — no TDs, no picks — but kept the game stable.
- Even with the wins, Oklahoma hasn’t looked like the dominant team from September.
- Missouri (6–2) has been unpredictable:
- Losses to Vanderbilt and Texas A&M were momentum killers.
- But they responded last week with 49 points on Mississippi State, scoring 14 points in nearly every quarter.
- Losses to Vanderbilt and Texas A&M were momentum killers.
- With Arkansas next week, this is Missouri’s last shot at staying playoff-adjacent.
Why it matters:
A Missouri upset injects them into the back-end playoff chaos; Oklahoma needs a convincing win to stay among the true contenders. Style points matter here. Missouri’s offense may quietly be cresting at the right time.
Pick: Missouri +6.5 – Oklahoma is winning but wobbling; Missouri has the offensive punch to keep this inside one score.
No. 15 USC at No. 7 Oregon Prediction
Line: Oregon -9.5
Storyline:
- Former Pac-12 foes meet in Eugene with enormous stakes.
- Oregon can essentially punch its playoff ticket here; only unranked Washington remains next week.
- The Ducks’ only loss came to Indiana, now a top two team — a “good loss” by committee standards.
- Oregon tuned up last week behind a nearly flawless showing:
- QB: 27/30 passing, 2 TDs.
- QB: 27/30 passing, 2 TDs.
- USC has stabilized:
- Coming off a win over No. 21 Iowa.
- Riding a three-game winning streak.
- Coming off a win over No. 21 Iowa.
- Both teams know this is a pseudo-elimination game.
Why it matters:
Oregon needs a strong win to solidify a top-four spot. USC, at 15 and streaking, still has an outside playoff window — a win here cracks it wide open.
Pick: Oregon ML + Over 59.5 – Oregon’s offense is too efficient at home, and USC can score enough to push this over the total. If playing live, wait for a better Ducks line.
Quick Picks
A few more on the card!
Michigan vs. Maryland
Pick: Over 45.57
No. 16 Georgia Tech vs. Pittsburgh
Line: Georgia Tech -2.5
Storyline Notes:
- Pitt was ranked recently but got blasted by No. 9 Notre Dame, allowing 37 points last week.
- They still sit at just one ACC loss — technically alive in the race.
- Georgia Tech, despite being No. 16, has flashed inconsistency:
- Loss to NC State
- Nearly lost to Boston College before scoring 19 in the 4th quarter to escape
- Loss to NC State
- QB Haynes King remains the engine:
- 50 rushing yards last week
- 370+ passing yards
- Just one TD, but efficient as a dual threat.
- 50 rushing yards last week
Pick: Georgia Tech -2.5 – King’s playmaking lifts them in a tricky matchup.
