Week 6 just delivered the kind of chaos that makes this season one of the most unpredictable in recent memory. It’s never too early to dive into our Week 7 betting preview to discuss NFL odds, matchups, and updates.
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Week 7 Betting Preview: NFL Odds, Updates and Predictions
The defending champion Eagles got boat-raced 34-17 by the 1-4 Giants behind rookies Jaxson Dart and Cam Skattebo.
The winless Jets recorded NEGATIVE passing yards in their London disaster against Denver.
Baker Mayfield’s MVP campaign rolled on with a 30-19 dismantling of San Francisco. And we got not one but TWO last-second field goal finishes in Panthers-Cowboys and Chargers-Dolphins.
The Eagles and Bills were undefeated darlings two weeks ago—now they’ve each dropped two straight. The Ravens entered as Super Bowl favorites and sit 1-5 without Lamar Jackson, staring at playoff elimination.
Meanwhile, the Colts are 5-1 with Daniel Jones playing actual NFL quarterback, and the Buccaneers are thriving at 5-1 despite missing half their receiving corps.
Let’s get into it.
Thursday Night Football: Steelers at Bengals
NFL Odds: (PIT -5.5, 43.5)
Pittsburgh sits at 4-1 behind Aaron Rodgers’ steady management and a defense that’s been dominant in primetime. Cincinnati is desperate at 2-4 after acquiring Joe Flacco, who showed competence in his Bengals debut but couldn’t close against Green Bay. This line opened at -4.5 and climbed to -5.5, telling you where sharp money landed early.
The Steelers’ defense has been surgical in division games, and Rodgers spreads the ball to eight different receivers while avoiding pressure beautifully.
The Bengals’ defense just surrendered 30-plus to multiple opponents and can’t generate consistent pressure. Thursday night home underdogs haven’t been profitable this season, but Cincinnati’s desperation creates an interesting dynamic.
Key Injury: Bengals DE Trey Hendrickson (back) left Week 6 early, and his status remains uncertain. His pass rush is critical for Cincinnati’s defensive identity.
London Game: Rams at Jaguars
NFL Odds: (LAR -3, 45)
This spread opened LAR -4.5 and dropped to -3, suggesting sharp action on Jacksonville. The Jaguars are 4-2 and riding high after their Monday Night upset over Kansas City.
The Rams dominated Baltimore’s depleted offense last week but now face a trickier spot: international travel combined with significant injury concerns.
Jacksonville’s defense features legitimate playmakers, and Trevor Lawrence proved in that Chiefs game that he can sling it when the moment demands. The Rams’ offensive efficiency depends heavily on their passing game staying healthy.
Key Injuries: Rams WR Puka Nacua (ankle) is day-to-day and questionable for London. He leads the NFL with 54 catches. Rams RB Blake Corum (ankle) is also banged up. Without Nacua, the Rams’ passing attack loses its most consistent target.
NFL Odds: Sunday Week 7 Games
Saints at Bears (CHI -5.5, 47.5) – Chicago rides a three-game winning streak but won their last two by identical 25-24 scores. New Orleans is figuring things out offensively after early struggles. The Bears laying 5.5 points at home represents a key number, and this total at 47.5 suggests oddsmakers expect offensive production from both sides.
Dolphins at Browns (CLE -3, 40.5) – Cleveland just scored nine points against Pittsburgh, yet they’re favored here. The total at 40.5 points is among the week’s lowest, reflecting two offenses that can’t consistently move the ball. The Browns’ offensive line issues persist, and Miami’s defensive problems compound weekly. That being said, Cleveland’s run defense has been electric.
Key Injuries: Browns’ TE David Njoku (knee hyperextension) left Week 6, and his availability is uncertain.
Raiders at Chiefs (KC -11.5, 45.5) – Kansas City demolished Detroit and looks rejuvenated. The Chiefs are getting Rashee Rice back from suspension, which significantly boosts their receiving corps. But 11.5 points in a division rivalry represents a massive number. Las Vegas always plays them tough at Arrowhead, and double-digit spreads in rivalry games tend to provide value on the underdog.
Eagles at Vikings (PHI -2.5, 43.5) – Philadelphia is reeling after two straight losses and has been outgained in all six games despite their 4-2 record. Minnesota gets two weeks to prepare after their bye; their defense is above average, and they’re getting 2.5 points at home. The Vikings’ QB situation with J.J. McCarthy remains uncertain.
Panthers at Jets (NYJ -2, 42.5) – The Jets are 0-6, just had negative passing yards in London, and they’re favored at home. This is one of the week’s most interesting market decisions. Bryce Young has shown improvement recently, Carolina just upset Dallas, and New York is dysfunctional on both sides. The question becomes whether the Jets’ home field and talent level overcome their complete lack of confidence.
Key Injury: Jets WR Garrett Wilson (knee hyperextension) is expected to miss 2-3 weeks. He led the team with 36 receptions for 395 yards and four touchdowns. Major loss.
Patriots at Titans (NE -7, 42) – Tennessee just fired head coach Brian Callahan after their 1-5 start, creating an interim coaching situation. The new coach bump is historically real in the NFL—teams often play harder immediately after a firing. Drake Maye has shown promise in his early starts.
Key Injury: Titans WR Calvin Ridley (hamstring) left Week 6 and didn’t return. His status for Week 7 will impact Tennessee’s already-limited passing attack. Big possible loss for TEN.
Giants at Broncos (DEN -7, 40) – New York just embarrassed Philly with their rookie duo of Dart and Skattebo dominating. Seven points is a significant spread for a Denver offense that’s been painfully mediocre despite elite defensive numbers. The total at 40 points is the week’s lowest. Jaxson Dart has rushed for 50+ yards in each of his first three NFL starts, joining Lamar Jackson and Jalen Hurts as the only QBs to accomplish that feat.
Colts at Chargers (LAC -1.5, 48.5) – Two 5-1 teams meeting with the Chargers as slight home favorites. This opened LAC -2.5 and shrunk to -1.5, indicating early sharp action on Indianapolis. Los Angeles is dealing with offensive line injuries but potentially getting key players back. Indianapolis features Daniel Jones thriving (22-of-30 for 212 yards and 2 TDs last week) and Jonathan Taylor bulldozing defenses.
[ad_unit slug=”sleeper”Key Injury: The Chargers had multiple offensive line injuries in Week 6. Monitor the practice report for tackle availability, as it significantly impacts Justin Herbert’s ability to operate.
Packers at Cardinals (GB -6.5, 44.5) – Green Bay is a solid road favorite, but Arizona plays them tough at home. The Cardinals’ offense can score on anyone when healthy, and Kyler Murray has been efficient this season – when healthy.
Key Injury: Cardinals WR Marvin Harrison Jr. (concussion – his third career) must clear protocol. His absence would significantly impact Arizona’s passing attack. Cardinals RB Emari Demercado (ankle) also left Week 6. Kyler Murray is still questionable, and he is the biggest key here.
Week 7: Sunday Afternoon Slate
Commanders at Cowboys (WAS -1.5, 54.5) – This game features the week’s highest total at 54.5 points, an absolutely massive number. Washington is 3-3 but coming off a tough Monday night loss. Dallas is 2-3-1 and has been dreadful at home this season. CeeDee Lamb’s status is critical—his return would significantly impact this spread and total.
Falcons at 49ers (SF -2.5, 47.5) – Will San Francisco be healthier by Sunday? Fred Warner is gone for the season. Atlanta is 3-3 and playing well behind Bijan Robinson’s dominance (176 total yards against Buffalo). This spread at 2.5 represents minimal respect for San Francisco’s home field, given their injury situation.
Key Injury: 49ers LB Fred Warner (season-ending broken and dislocated ankle) is a catastrophic loss for their defense. He was the quarterback of that unit.
Monday Night Football Preview and NFL Odds
Buccaneers at Lions (DET -5.5, 52.5) – The week’s marquee matchup features two top-five scoring offenses. The Lions catch Tampa Bay at an interesting time—the Bucs are dealing with multiple receiver injuries. Detroit’s offense has been unstoppable at home, and this total at 52.5 reflects expectations for an offensive showcase in the dome.
Key Injuries: Buccaneers WR Emeka Egbuka (hamstring, 1-4 weeks) joins Mike Evans and Chris Godwin on the injury report. Will Evans be back? He’s questionable. Tampa Bay’s receiver depth is being tested hard. Lions are relatively healthy, but their defense has shown vulnerability against elite offenses.
Texans at Seahawks (SEA -3.5, 41) – Seattle is 3-3 but deadly at home, where their pass rush creates havoc. Houston is 3-3 after their bye, but has been inconsistent on offense all season. The Seahawks’ home crowd provides a significant advantage in night games. This total at 41 points suggests both defenses can get stops, a contrast to the earlier Monday night game.
