NCAA Tournament Sweet 16 Props: South Region

Kyler Edwards #11 and Reggie Chaney #32 of the Houston Cougars celebrate after defeating the Illinois Fighting Illini 68-53 during the second round of the 2022 NCAA Men's Basketball Tournament at PPG PAINTS Arena on March 20, 2022 in Pittsburgh, Pennsylvania.
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The NCAA South Region Sweet 16 involves three top teams – Arizona, Villanova, and Houston – along with Michigan, a team that reached the Elite Eight last season and appears to be peaking at the right time.

As the number of games falls deeper into the NCAA Tournament, props become more attractive for bettors who like to have action on multiple fronts. breaks down four available NCAA Tournament prop bets for Thursday’s South Region Sweet 16 games: No. 1 seed Arizona vs. No. 5 Houston, and No. 2 Villanova vs. No. 11 Michigan.

Odds via DraftKings as of 1:45 p.m. ET on March 24.

NCAA Tournament Sweet 16 Props: Arizona Vs Houston

Time: 9:59 p.m. ET
Spread/Total: Arizona -1.5/146.5

Houston Cougars: Team Total

Houston Cougars forward Josh Carlton (25) looks on during the 3rd place college basketball game in the Maui Invitational between the Houston Cougars and the Oregon Ducks on November 24, 2021, at the Michelob ULTRA Arena in Las Vegas, NV.
Image Credit: Brian Rothmuller/Icon Sportswire via Getty Images

The prop: Houston 73.5 total points
The odds: Over -105/Under -125

Arizona vs. Houston will be a battle of pace. The Wildcats rank fifth nationally in tempo, according to, while the Cougars are 334th out of 358 Division I teams.

Houston has consistently won the pace game in the NCAA Tournament. In the Cougars’ four straight NCAA trips under coach Kelvin Sampson, they are 9-3 SU despite cracking 70 points only four times – and three of those were as heavy favorites in first-round games against overmatched opponents.

Beyond the opening round, Houston scored more than 70 points only in a 74-59 second-round victory over No. 11 seed Ohio State in 2019.

Last season, Houston reached the Final Four by scoring 63, 62, and 67 points in the second round through the Elite Eight, respectively, then scored 59 in a loss to Baylor in the national semifinals.

Arizona likes to press the pace, but that could change in a high-stakes, tight battle with an Elite Eight berth on the line. Take the Under on this prop.

Arizona Wildcats: F Christian Koloko

Christian Koloko #35 of the Arizona Wildcats shoots the ball against Emanuel Miller #2 of the TCU Horned Frogs during the second half in the second round game of the 2022 NCAA Men's Basketball Tournament at Viejas Arena at San Diego State University on March 20, 2022 in San Diego, California.
Image Credit: Sean M. Haffey/Getty Images

The prop: 12.5 points
The odds: Over -140/Under +105

The Arizona center went off for 28 points in the Wildcats’ 85-80 overtime win against TCU in the second round, but he could find much tougher sledding against Houston.

Besides TCU, Arizona has played eight games this season against teams ranked in the top 30 defensively by KenPom – three against UCLA, two against Arizona State, and one against Illinois, Tennessee and Washington State. In those games, Koloko has averaged 8.25 points, with a high output of 13 against UCLA in the Pac-12 tournament final.

In other words, Koloko’s outburst against TCU screams “outlier”.

As mentioned above, Houston will also be looking to slow this game down and limit possessions.

NCAA Tournament Sweet 16 Props: Villanova Vs Michigan

Time: 7:29 p.m. ET
Spread/Total: Villanova -5/135.5

Villanova Wildcats: Alternate Spread

Head coach Jay Wright and Jermaine Samuels #23 of the Villanova Wildcats look on in the second half against the St. John's Red Storm during the 2022 Big East Tournament at Madison Square Garden on March 10, 2022 in New York City.
Image Credit: Tim Nwachukwu/Getty Images

The prop: Villanova -10.5 (alternate spread)
The odds: +215

Michigan has salvaged a disappointing season by fighting into the Sweet 16, but the Wolverines are consensus 5-point underdogs against Villanova on Thursday. Clearly, oddsmakers expect them to lose.

Well, when Michigan loses, it’s usually not close. The Wolverines have lost 14 games this season, and nine were by 10 points or more. Two others were eight-point defeats.

Also, Villanova is No. 1 in the country in free-throw percentage. Which means the Wildcats are the right team to turn a six-point lead with a minute left into a 12-point victory by the time all the fouling and free throws are done.

The Wildcats have alternate spreads available at DraftKings, ranging from -6 (+105) to -10.5 (+215).

Villanova Wildcats: G Caleb Daniels

Caleb Daniels #14 of the Villanova Wildcats is defended by Kevin Anderson #1 of the Delaware Fightin Blue Hens during the first round of the 2022 NCAA Men's Basketball Tournament held at PPG PAINTS Arena on March 18, 2022 in Pittsburgh, Pennsylvania.
Image Credit: Justin K. Aller/NCAA Photos via Getty Images

The prop: 1.5 made 3-pointers
The odds: Over -115/Under -115

Villanova guard Caleb Daniels made only one 3-pointer in the Wildcats’ second-round victory over Ohio State, but that has not been the norm. For the season, Daniels has made two or more 3-pointers in 17 of his 32 games. In the other 15, he drained one triple nine times and zero in the other six — though three of those bagels were in the first three games of the season.

More recently, Daniels has made two or more 3-pointers in six of his past nine contests, including three in Villanova’s first-round win over Delaware. The last time Daniels was held without a 3 was Feb. 5 against Connecticut.