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College Football Week 15 Predictions: Picks, Odds & Preview

Sam Pasco

Sam Pasco

Last updated: December 5, 2025

College Football Week 15 Predictions - Fernando Mendoza

Welcome to our College Football Week 15 predictions! We’ll look at the top games of the day, odds on the betting board, and what that means for our favorite CFB picks and player props.

Check our NCAAF News Hub for all things Week 15!

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College Football Week 15 Predictions and Picks

Welcome to Conference Championship Week — the real hinge point of the season. While Week 16 technically exists for the annual Army–Navy game (Army sits as a 4.5-point favorite next Saturday), Week 15 is where the playoff field truly takes shape.

Across Friday and a loaded Saturday slate, we’ve got title games, undefeated seasons on the line, quarterback duels, and several spots where chaos could hit the rankings hard.

Let’s dive into the matchups, the momentum, and the picks.

Sun Belt Championship: Troy at No. 25 James Madison

Line: JMU -23.5
Total: 47.5

James Madison has been an offensive avalanche all year. Their lone loss came in Week 2 to Louisville — and outside of that blip, they’ve crushed nearly everyone in their path.

  • 50+ points in 4 of their last 6 → Even their “quiet” games: 24 and 35 points

Troy, meanwhile, has no business stumbling into this title matchup. Four losses — including getting shut out by Old Dominion — show just how inconsistent this team has been. Their offense simply hasn’t shown the staying power to keep pace.

This profiles as a blowout from the opening kick.

Pick: JMU -23.5

American Athletic Championship: No. 24 North Texas at No. 20 Tulane

Line: North Texas -2.5
Total: 67.5

North Texas has become one of the breakout stories of 2025, entering championship weekend with just one loss — a high scoring battle against then-No. 24 USF.

The engine of this team? QB Drew Mestemaker, who’s been a revelation:

  • 29 TDs, just 4 INTs
  • Nearly 4,000 yards passing
  • Top-25 nationally in QBR

Tulane is tough, experienced, and well-coached, but North Texas has been the more dynamic team all season. Their vertical passing attack has consistently overwhelmed AAC defenses, and Mestemaker has played some of his best football under pressure.

This feels like the North Texas breakthrough moment.

Pick: North Texas -2.5

Saturday, December 7 — Championship Saturday

Saturday features four title games staggered across the day — one at noon, one mid-afternoon, and two in primetime.

Big 12 Championship — No. 11 BYU vs. No. 4 Texas Tech

Line: Texas Tech -12.5
Total: 49.5

BYU has been solid behind Stanford transfer Bear Bachmeier, a freshman who’s stabilized the Cougars:

  • 2,500 yards
  • 14 TDs, 4 INTs

But BYU’s résumé is thin — only one ranked win (Utah), and a midseason loss to Texas Tech where the offense sputtered badly.

Texas Tech has been the real hammer down the stretch:

  • Opponents under 10 points in 3 straight games
  • 4 of their last 5 opponents held below 10
  • Efficient, physical, suffocating defense

With both teams sharing a 1–1 record vs ranked opponents, this comes down to recent form — and Texas Tech looks like a playoff-caliber machine right now.

Pick: Texas Tech ML

SEC Championship: No. 9 Alabama vs. No. 3 Georgia

Line: Georgia -2.5
Total: 47.5

The SEC Championship delivers its usual chaos potential.

Alabama QB Ty Simpson remains firmly in the Heisman conversation:

  • 3,000+ yards
  • 30 TDs / 4 INTs
  • Won 27–20 last week with 3 TDs vs Auburn despite 3 sacks
  • Season-high 31 rushing yards last week, showing some added versatility

His only recent blip? A two-INT game vs Eastern Illinois — a weird outlier in an otherwise elite season.

Georgia’s only loss this year came to Alabama in Week 4 — a 24–21 defensive fistfight where:

  • Both teams went scoreless in the 4th
  • Bama was shut out the entire second half
  • Georgia QB Gunner Stockton was steady (2 TDs, 1 via air, 1 on ground) but unspectacular

With playoff stakes burning hot, expect another low-tempo grinder.

Pick: Alabama +2.5
Pick: Under 47.5

Big Ten Championship: No. 1 Ohio State vs. No. 2 Indiana

Line: Ohio State -4
Total: 47.5

The game of the day — two undefeated teams, two Heisman favorites, and a winner-to-the-one seed guarantee.

Ohio State’s Julian Sayin has been dynamic:

  • 3,000+ yards
  • 30 TDs, 5 INTs

But Indiana QB Fernando Mendoza has cemented himself as one of the elite playmakers in the country:

  • Extremely efficient against Purdue last week
  • 6 TDs, 0 INTs over his last two games
  • Calm, controlled, and explosive when needed

The concern: Indiana hasn’t faced many ranked teams. But Mendoza gives them a puncher’s chance in any setting — and this feels like the exact kind of game where a special quarterback steals the spotlight.

Pick: Indiana +4

ACC Championship: Duke vs. No. 17 Virginia

Line: Virginia -4
Total: 57.5

The ACC has been a beautiful mess all season — and now a 7–5 Duke team plays for a conference title.

Duke’s offense has quietly found real rhythm:

  • 30+ points in back-to-back games

Virginia, though, has been just as hot:

  • 27+ points in 3 of their last 4
  • Won this exact matchup two weeks ago, 37–17
  • Led 31–3 heading into the 4th before coasting

The Cavaliers are the better team on both sides of the ball, and while Duke’s surge is fun, Virginia looks too balanced and too prepared.

Pick: Virginia -4
Pick: Under 57.5

Final Thoughts: Summary of Week 15 Picks

  • Sun Belt: JMU -23.5
  • AAC: North Texas -2.5
  • Big 12: Texas Tech -12.5
  • SEC: Alabama +2.5 & Under 47.5
  • Big Ten: Indiana +4
  • ACC: Virginia -4 & Under 57.5

Conference Championship Week is never predictable — but this slate is packed with explosive offenses, quarterback duels, revenge spots, and real playoff stakes. Buckle up: Saturday has the potential to reshape the entire postseason picture.

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