Check out our Sixers vs Cavs prediction and NBA expert picks for Wednesday, November 5th! Our hoops analyst Justin Carlucci brings you his favorite Sixers-Cavs props and betting angles to consider. We’ll discuss Tyrese Maxey props, as he’s playing like a true MVP candidate.
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Sixers vs Cavs Prediction – NBA Game Preview: Wednesday, November 5th
The Cleveland Cavaliers are -10 home favorites against a Philadelphia 76ers team playing the second night of a back-to-back without Joel Embiid. This matchup features one of the most explosive scoring performances of the 2025-26 season: Tyrese Maxey’s 34.4 PPG average against Donovan Mitchell’s 29.5 PPG. Here’s everything you need to know about tonight’s Sixers vs Cavaliers props and Tyrese Maxey props.
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Sixers vs Cavaliers Odds
Looking for 76ers-Cavs odds tonight?
- Spread: Cavs -10
- Moneyline: 76ers +310 (available at time of publishing)
- Game Total: 235.5 (subject to change)
Sixers vs Cavaliers Prediction: Why Cleveland Feels Like A Lock Tonight
The Sixers vs Cavaliers prediction is straightforward: the Cavaliers should dominate. Here’s why.
Philadelphia is playing its second game in as many nights after losing to Chicago 111-113 last night. They’re on the road in Cleveland without Joel Embiid (back-to-back rest management), without Paul George (knee surgery recovery), and with zero depth in the frontcourt.
The Cavaliers, meanwhile, are well-rested at home with a deep roster led by Donovan Mitchell and elite rim-protector Evan Mobley.
This is the classic “trap game” setup—a depleted road team on B2B facing a fresh, talented home squad. The Cavaliers’ -10 spread is justified, and there’s a legitimate case for taking them at even worse odds if you can find them.
Team Records & Season Context
Philadelphia 76ers: 5-2 (3-1 Road)
The 76ers are winning despite injuries because Tyrese Maxey is playing at an MVP level. When healthy (Embiid + George available), this is a contender. But tonight? They’re skeletal. Andre Drummond and Quentin Grimes will have to hold down the fort in the paint against Evan Mobley—a complete mismatch.
Cleveland Cavaliers: 4-3 (2-1 Home)
The Cavs are constructed perfectly for a playoff run. Mitchell is an elite scorer, Mobley is a two-way anchor, and their defense ranks among the league’s best. At home, this team is suffocating. They’re 2-1 in Quicken Loans Arena for a reason—the ball movement, the perimeter shooting, the interior defense. It’s a machine.
Sixers vs Cavs Props and Picks Today
There are plenty of Sixers-Cavs player props to choose from on Underdog for Wednesday. Let’s dive into the Cleveland vs Philadelphia predictions!
Sixers vs Cavs Prediction: Tyrese Maxey Props & Picks
- Higher/Lower 33.5 Points – LEAN HIGHER. Maxey is averaging 34.4 PPG and will see volume tonight. With Embiid out, opposing defenses will focus on him, but Maxey has proven he can handle the defensive pressure. He dropped 45 points in one game this season. The Cavaliers’ perimeter defense is solid but not lockdown. Expect Maxey to launch 25+ shots.
- Higher/Lower 7.5 Assists – LEAN LOWER. Without Embiid, Maxey becomes the primary playmaker, but he’s a scorer first. He’s averaging 8.4 APG, so this is close to his average. The Cavs will make him work on defense, which could eat into assist opportunities.
Sixers vs Cavs Prediction: Donovan Mitchell Props & Picks
- Higher/Lower 28.5 Points – LEAN HIGHER. Mitchell is at 29.5 PPG and playing at home against a tired 76ers defense. He dropped 37 against Atlanta three days ago. Fresh, at home, against B2B opponents? Mitchell hits this easily.
- Higher/Lower 5.5 Assists – LEAN HIGHER. Mitchell is a playmaker for the Cavs, and the ball movement is excellent. He’s been facilitating more as the season progresses.
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