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Week 4 NFL Props: Pick’em Cheat Sheet

Props Staff

Props Staff

Last updated: September 27, 2025

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Check out our expert Week 4 NFL props for this weekend! This cheat sheet is your go-to quick stop to fire in some picks!

The madness of the NFL hasn’t stopped!

There have been dozens of injuries and personnel changes that are certain to shake things up this coming weekend.

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Week 4 NFL Props: Pick’em Cheat Sheet

Here’s our cheat sheet that highlights our favorite Week 4 NFL props in every matchup!

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Minnesota Vikings @ Pittsburgh Steelers

Pick: T.J. Hockenson Higher Than 37.5 Receiving Yards – The tight end finished with 46 yards last week and was more involved (25% target share) with Carson Wentz under center. Expect that role to continue with the QB change. 

Washington Commanders @ Atlanta Falcons

Pick: Darnell Mooney Higher Than 41.5 Receiving Yards – This projection is very reasonable for a guy with a 23.4% target share through two games. Mooney cleared this projection in 10 of 15 healthy games last season with a 19.6% target share. 

New Orleans Saints @ Buffalo Bills

Pick: Juwan Johnson Any Time Touchdown Scorer – Do the Saints play fast? Yes. Are they heavy underdog, likely to throw a lot? Yes. Does Johnson have good odds? Yes.

Cleveland Browns @ Detroit Lions

Pick: Quinshon Judkins Higher Than 57.5 Rushing Yards – Via Fantasy Points data, the Browns have been deploying nearly a 50% man/gap scheme when running the football, and Detroit hasn’t been great against that specific approach compared to zone-blocking concepts.

Carolina Panthers @ New England Patriots

Pick: Drake Maye Higher Than 208.5 Passing Yards -The Patriots are already throwing the ball at the 10th-highest rate in neutral situations league-wide (via Fantasy Points), which indicates they’re comfortable letting Maye drop back consistently.

Los Angeles Chargers @ New York Giants

Pick: Darius Slayton Higher Than 18.5 Receiving Yards – Slayton is playing a TON and just getting some cardio. He can’t get targeted much less than when Wilson was at the helm. Things should only go up in terms of production.

Philadelphia Eagles @ Tampa Bay Buccaneers

Pick: Emeka Egbuka Higher Than 59.5 Receiving Yards – Mike Evans is out and Chris Godwin is coming off a major ankle injury. Egubuka owns a 21.2% target share and 24.6% first-read rate alongside Evans this season, and Godwin is potentially limited in his return. 

Tennessee Titans @ Houston Texans

Pick: Nico Collins Higher Than 72.5 Receiving Yards – The Texans alpha receiver exploded for 8 receptions and 104 yards last week. This projection is a touch low for the top option in the offense with a 28.1% target share.   

Indianapolis Colts @ Los Angeles Rams

Pick: Daniel Jones Higher Than 246.5 Passing + Rushing Yards – Jones has cleared this projection all three games so far. With the Colts entering play as underdogs, there should be plenty of volume for Jones in the air and he is always a threat to run. 

Jacksonville Jaguars @ San Francisco 49ers

Pick: Christian McCaffrey Higher Than 46.5 Receiving Yards – Brandon Aiyuk and George Kittle are still absent from the passing attack. McCaffrey has a massive 26.5% target share so far this season. 

Baltimore Ravens @ Kansas City Chiefs

Pick: Zay Flowers Higher Than 58.5 Receiving Yards – The Chiefs deploy a boatload of two-high coverage, which historically creates exactly the type of underneath opportunities that should be screaming Flowers’ name. Baltimore has to get him more involved than last week.

Chicago Bears @ Las Vegas Reiders

Pick: Rome Odunze Higher Than 4.5 Receptions – Potential shootout in Vegas. Odunze is the clear alpha in the Bears passing attack with a 27.1% target share and 32.2% first-read rate. 

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