Sharp Selections: Week 6 MNF PrizePicks NFL Preview

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As we gear up for Monday Night Football, there are two standout PrizePicks plays worth locking in. This week’s matchup between the New York Jets and Buffalo Bills offers great opportunities for value with both Breece Hall and James Cook.

Let’s break down why these plays should be part of your Monday night lineup.

Monday’s Sharp Selections: Week 6 MNF PrizePicks NFL Preview

Let’s run through these plays and the reasons behind each pick, so you can take full advantage this week.

Play 1: Breece Hall More Than 14.5 Fantasy Score

Breece Hall has a favorable setup heading into Monday night, and taking more than 14.5 fantasy score looks like a great value play. With -115 odds to score a touchdown, Hall is in a prime spot to add six points to his fantasy total right off the bat. But that’s not the only reason to like Hall in this matchup.

Hall is projected for nearly 70 rushing yards, and the Bills’ defense has shown weaknesses against opposing running backs. Buffalo has allowed the most receptions and targets to backs this season, and Hall is expected to see plenty of work in the passing game as well, with -140 odds to grab at least 4 receptions. Additionally, the Bills have given up the 8th most rushing attempts and rushing yards to opposing backs, and Hall is projected for nearly 16 carries.

The fantasy score format is ideal here, as Hall has multiple ways to cash—whether it’s through rushing yards, receptions, or finding the end zone. With everything pointing to a high-usage game for Hall, this is one of my favorite plays for Monday night.

James Cook ruled OUT for Monday Night Football Week 6

Play 2: James Cook More Than 14 Rush Attempts

James Cook is another player in a favorable situation on Monday night, with his PrizePicks number set at 14 rush attempts. Cook is projected for more than 16 carries in this matchup, making this a great value pick. The Bills will likely look to control the pace of the game, and Cook has been receiving about 60% of his team’s running plays this season.

Opposing running backs have been able to rack up rushing attempts against the Jets, who have allowed the 11th most rush attempts in the league. With Buffalo expected to rely on Cook to manage the ground game and wear down the Jets’ defense, it’s easy to see him clearing 14 carries in this contest.

Cook’s workload has been consistent, and with the game script potentially favoring the run, he’s in a great position to hit more than 14 rush attempts.

Final Thoughts: Monday Night Football Must-Hit PrizePicks Plays

Here’s a quick recap of the best PrizePicks plays for Monday night’s Jets vs. Bills game:

  1. Breece Hall More Than 14.5 Fantasy Score – With a projected touchdown, rushing yards, and a solid role in the passing game, Hall is in a great spot to surpass 14.5 fantasy points.
  2. James Cook More Than 14 Rush Attempts – Cook’s consistent usage and favorable matchup against the Jets make this a strong pick for Monday night.

Both of these plays are backed by solid data, favorable game scripts, and strong projections, making them excellent picks to include in your PrizePicks entry for Monday Night Football.

Tip of the Day: Play to Strengths and Game Flow

When selecting your PrizePicks plays, always consider the game script and how each player fits into their team’s plan. For running backs, focus on how many touches they’re likely to get and whether the matchup encourages more rushing or passing.

Players like Breece Hall, who have multiple ways to accumulate points through both the ground and air, offer additional value in fantasy score formats. Betting on volume, especially for backs expected to be heavily involved, can give you an edge in making smart plays.

Good luck, and let’s make this Monday night a winning one!