You’re in the right place for Week 12 Monday Night Football prop ladders and predictions. We’ll try and locate 49ers-Panthers props that offer the most value.
Week 12 MNF brings us a matchup between the San Francisco 49ers and Carolina Panthers, and our analyst Justin Bales is here to find us some winners. Let’s dive into a few player props.
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Week 12 Ladders: 49ers/Panthers Props & Predictions
We have a great Monday Night Football game on the board for Week 12 Let’s dive into our top 49ers-Panthers player props!
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Christian McCaffrey Receiving Yards Ladder
McCaffrey is one of the best receiving backs in the NFL, and he’s consistently found success in this area. He’s recorded 74 receptions for 732 yards and 5 touchdowns on 89 targets this season. He’s also posted 40+ receiving yards in each of his 11 games in 2025.
San Francisco’s star running back isn’t a typical option out of the backfield. He’s seen plenty of screens behind the line of scrimmage, but he’ll also see targets deeper down the field. Occasionally, the 49ers will take shots to him, which generally isn’t something running backs see.
This isn’t an ideal matchup for McCaffrey. The Carolina Panthers are only giving up 29.4 receiving yards per game to running backs. They’re also giving up 4.9 receptions on 6.4 targets, and McCaffrey will be their hardest challenge to date.
Where to Bet: Christian McCaffrey 40+ receiving yards (-146) through 80+ receiving yards (+470)
George Kittle Receiving Yards Ladder
Kittle’s only played in six games for the San Francisco 49ers this season. He’s dealt with injuries early on, but he looks fully healthy at this point. Overall, he boasts 27 receptions for 251 yards and 5 touchdowns on 29 targets.
The veteran tight end is coming off his best two games of the season. He’s posted 84 and 67 yards over his two games. He also posted 100+ receiving yards in four games last season, flashing that he still comes with tremendous upside when given the targets.
Kittle will face off against the Carolina Panthers, who have struggled against tight ends this season. They’re giving up 5.3 receptions on 6.7 targets per game to the position. The Panthers are also allowing the seventh-most receiving yards (65.3) per game to opposing tight ends.
Where to Bet: George Kittle 50+ receiving yards (-166) through 100+ receiving yards (+520)
Tetairoa McMillan Receiving Yards Ladder
McMillan has flashed incredible talent as a rookie for the Carolina Panthers this season. He’s posted 54 receptions for 748 yards and 4 touchdowns on 86 targets. He hasn’t been the most consistent player on the field, but he boasts high-level upside.
The rookie is coming off his best game of the season in Week 11. He posted 8 receptions for 130 yards and 2 touchdowns on 10 targets against the Atlanta Falcons. He’s also seen games with 100 and 99 yards this season.
McMillan gets a great matchup against the San Francisco 49ers this week. They’re giving up the fourth-most receiving yards (165.1) per game to opposing wide receivers this season. The 49ers are also allowing 13.6 receptions on 19.5 targets per game to the position.
This matchup works well for McMillan, who is a big-play threat. The 49ers are giving up over 12 yards per reception in 2025, and the rookie boasts the ability to cover most of this ladder with one reception.
Where to Bet: Tetairoa McMillan 60+ receiving yards (-152) through 100 receiving yards (+290)
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